镁蔷薇辉石的生物活性

Bioactivity of Merwinite Ceramic

用溶胶-凝胶法制备出纯相镁蔷薇辉石(Ca3MgSi2O8)陶瓷,通过模拟体液浸泡和体外成骨细胞共培养对其体外生物活性进行了研究.XRD、SEM和EDS的结果表明,该陶瓷在模拟体液浸泡7 d后就在其表面沉积有碳酸羟基磷灰石(CHA),浸泡14 d后其表面出现呈蠕虫状结构结晶较好的碳酸羟基磷灰石.材料与细胞的共培养试验表明:与磷酸三钙(β-TCP)对比,该陶瓷更能促进成骨细胞的贴壁、黏附和铺展.

Mono-phase glass-ceramics of merwinite （ Ca3 MgSi2O8 ） was prepared by sintering merwinite powder compacts derived from sol-gel technics. The bioactivity of merwinite ceramic was evaluated systematically in vitro. The surface physicochemical change of merwinite ceramic soaking in a simulated physiological fluid （Kokubo s SBF）for various periods are detected by XRD, SEM and EDS analysis. The results show that the carbonate-containing hydroxyapatite （CHA） layer is formed on the surface of merwinite ceramics after 7 days soaking in SBF solution. The worm-like crystallite CHA was formed on the merwinite after soaking in SBF solution for 14 days. Prior to the formation of the CHA layer, silica-rich layer appears on the surface of merwinite soaked in SBF solution. The formation of CHA layer on merwinite surface indicates a good bioactivity, The interaction of osteoblastic cells with the surface of the material shows a significant cell proliferation on the surface of merwinite compaed with β-tricalcium phosphate（β-TCP）.