脐带血间充质干细胞的研究进展
摘要
近年研究结果表明，除了造血干细胞外，脐带血中还存在与骨髓间充质干细胞（mesenchymal stem cell，MSC）相似的细胞群，这类细胞在特定诱导条件下可向多种组织细胞分化。由于脐带血具有资源丰富、采集简单且无损伤等优势，如果对脐带血MSC进行开发和应用，将能为组织工程提供新的种子细胞，对干细胞组织工程及其应用具有深远意义。现就目前相关研究做一综述。
出处
《中国医师进修杂志（内科版）》
2007年第5期70-72,共3页
Chinese Journal of Postgraduates of Medicine
参考文献17
-
1Wexler SA, Donaldson C, Denning - Kendall P, et al. Adult bone marrow is a rich source of human mesenchymal ' stem' cells but umbilical cord and mobilized adult blood are not. Br J Haernatol, 2003,121 (2) :368 - 374.
-
2Yu M, Xiao Z,Shen L, et al. Mid - trimester fetal blood - derived adherent cells share characteristics similar to mesenchymal stem cells but full - term umbilical cord blood does not. Br J Haematol, 2004, !24(5) :666 -675.
-
3Goodwin HS, Bicknese AR, Chien SN, et al. Multillneage differentiation activity by cells isolated firm umbilical cord blood : expression of bone, fat, and neural markers. Biol Blood Marrow Transplant,2001,7( 11 ) :581 -587.
-
4程范军,邹萍,仲照东,郭荣,肖娟.人脐血间充质干/祖细胞的生长特征[J].中国实验血液学杂志,2003,11(6):565-568. 被引量：10
-
5Lu FZ, Fujino M, lrdtazawa Y, et al. Characterization and gene transfer in mesenehymal stem cells derived firm human umbilical -cord blood. J Lab Clin Med, 2005, 146(5) :271 -278.
-
6Tondreau T, Meuleman N, Delforge A, et al. Mesenchymal stem cells derived from CD133 -positive cells in mobilized peripheral blood and cord blood: proliferation, Oct4 expression, and plasticity. Stem Cells,2005, 23(8) :1105 - 1112.
-
7Chang YJ, Shih DT, Tseng CP, et al. Disparate mesenchyme- lineage tendencies in mesenchymal stem cells from human bone marrow and umbilical cord blood. Stem Cells, 2006,24:679 -685.
-
8Kern S, Eichler H, Stceve J, et al. Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells, 2006,24 (5) : 1294 - 1301.
-
9Hong SH, Gang E J, Jeong JA, et al. In vitro differentiation of human umbilical cord blood -derived mesenchymal stem cells into hepatocyte-like cells. Biochem Biophys Res Commun, 2005,330(4) :1153 -1161.
-
10McGuckin CP, Forraz N, Allouard Q, et al. Umbilical cord blood stem cells can expand hematopoietic and neuroglial progenitors in vitro. Exp Cell Res, 2004, 295(2) :350 -359.
二级参考文献17
-
1[1]Pereira R F, Halford K W, O'Hara M D, et al. Cultured a dher ent cells from marrow can serve as long-lasting precursor cells for bone ,carti lage, and lung in irradiated mice[J]. Proc Natl Acad Sci USA,1995,92(11):4 857-4 861.
-
2[2]Prockop D J. Marrow stromal cells as stem cells for nonhematopoieti c tissues[J]. Science,1997,276(5 309):71-74.
-
3[3]Pittenger M F, Mackay A M, Beck S C, et al . Multilineage poten tial of adult human mesenchymal stem cells[J]. Science,1999,284(5 411):143-14 7.
-
4[4]Richards M, Huibergtse B A, Caplan A I, et al. Marrow-derives progenitor cell injections enchance new bone formation during distraction[J]. J Orthop Res,1999,17(6):900-908.
-
5[5]Awad H A, Butler D L, Boivin G P, et al. Autologous mesenchymal stem cell-mediated repair of tendon[J]. Tissue Eng,1999,5(3):267-277.
-
6[6]Kopen G C, Prockop D J, Phinney D G. Marrow stromal cells migrate t hroughout forebrain and cerebellum, and they differentiate into astrocytes after injection neonatal mouse brains[J]. Cell Biology,1999,96(19):10 711-10 7 16.
-
7[7]Ohgushi H, Caplan A I. Stem cell technology and biocramics: from ce ll to gene engineering[J]. J Biomed Mater Res,1999,48(6):913-927.
-
8[8]Conget P A, Minguell J J. Phenotypical and functional properties of human bone marrow mesenchymal progenitor cells[J]. J Cell Physiol,1999,181(1 ):67-73.
-
9[1]Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science, 1999; 284(5411): 143-147
-
10[2]Zvaifler NJ, Marinova-Mutafchieva L, Adams G, et al. Mesenchymal precursor cells in the blood of normal individuals. Arthritis Res, 2000; 2:477-488
共引文献57
-
1马宏图,睢凤英,惠斌,宋国杰.不同诱导体系体外诱导大鼠骨髓干细胞分化为肝细胞的实验研究[J].陕西师范大学学报（自然科学版）,2009,37(S1):34-37.
-
2艾国平,粟永萍,闫国和,王蒙,刘晓宏,程天民.创面微环境对植入骨髓间充质干细胞的影响研究[J].第三军医大学学报,2003,25(13):1134-1136. 被引量：7
-
3吕铁伟,田杰,朱静,刘官信.大鼠骨髓间充质干细胞适宜分离和培养条件的研究[J].重庆医科大学学报,2004,29(6):715-717. 被引量：12
-
4黄钢丁,姜海行.人脐血干细胞的特性及其肝细胞分化的研究进展[J].医学文选,2005,24(1):109-111. 被引量：3
-
5法宪恩,王利霞,侯剑峰,张瑞成,王海永,杨辰垣.人骨髓间充质干细胞体外培养及生物学特性观察[J].郑州大学学报（医学版）,2005,40(3):445-447. 被引量：5
-
6洪雁,黄文越.神经干细胞移植治疗帕金森病的研究进展[J].中原医刊,2005,32(15):46-47. 被引量：1
-
7樊友启,王建安.人骨髓间充质干细胞的培养与鉴定[J].全科医学临床与教育,2005,3(3):142-144. 被引量：1
-
8万荣,聂广.骨髓干细胞:肝细胞移植的新来源[J].中国中西医结合消化杂志,2005,13(5):345-347. 被引量：2
-
9法宪恩,王利霞,侯剑峰,张瑞成,王海永.5-氮胞苷诱导骨髓间充质干细胞向心肌样细胞分化观察[J].郑州大学学报（医学版）,2005,40(6):1056-1059. 被引量：4
-
10韦育林,李楚强,伍卫,傅玉如,魏菁,梁尉文.大鼠骨髓间充质干细胞生长特性和表面标志与培养基中胎牛血清浓度的关系[J].中国临床康复,2006,10(1):28-30. 被引量：6
-
1李东风 ,王鹏程 ,徐明瑜 .机械刺激对骨髓间充质干细胞分化的影响[J].国外医学（生物医学工程分册）,2005,28(4):234-236.
-
2徐友高,韦晓谋,吴振.人骨髓间充质干细胞的分离培养[J].柳州医学,2005,18(3):152-153.
-
3王豪勋,段芳龄,马军,梅雪,程香普,郑鹏远,唐芙爱.骨髓间充质干细胞治疗肝硬化的实验研究[J].胃肠病学和肝病学杂志,2005,14(3):277-278. 被引量：3
-
4王麟.“打印”器官再移植[J].科学之友,2003(6):22-22.
-
5戴芳,宋莉.骨髓间充质干细胞与相关载体的联合应用及调控[J].南昌大学学报（医学版）,2010,50(2):115-117.
-
6曹玄林.干细胞的应用研究现状[J].河北医药,2002,24(5):343-344.
-
7杨雯,惠玲,吕同德.人脐带间充质干细胞向血管内皮细胞的定向分化及临床应用进展[J].解放军医药杂志,2013,25(10):26-30. 被引量：3
-
8秦安清,刘黎青,于娜,周盛年.骨髓间充质干细胞向神经元样细胞分化的研究进展[J].陕西中医,2010,31(3):378-380. 被引量：1
-
9施明,刘拥军,王福生.人间充质干细胞治疗肝病研究进展及前景[J].肝脏,2009,14(6):483-486. 被引量：1
-
10盛辉,王洪复.骨髓基质细胞向成骨细胞诱导分化的研究进展[J].中国骨质疏松杂志,2004,10(1):98-102. 被引量：6
