脂代谢紊乱和脂肪细胞因子与胰岛素抵抗

Lipid dysmetabolism, adipocytokine and insulin resistance

糖和脂代谢异常同属于2型糖尿病的原发病理生理事件,也是胰岛素抵抗(IR)发生和发展的主要特征。游离脂肪酸的异常在IR的形成中具有至关重要的作用,而一些具有活跃的代谢作用及复杂生理功能的脂肪细胞因子与糖、脂代谢及IR也具有双向的调节作用。

Glucose and lipid dysmetabolism, as the pathophysiological basis of T2DM, is the principal characteristics of insulin resistance. Abnormalities of free fatty acids （FFAs） play an important role in the pathogenesis of insulin resistance. And adipocytokines that have complicated physiological and metabolic function, can regulate glucose and lipid metabolism and alter insulin sensitivity.