中国人胆固醇酯转运蛋白TaqIB基因多态性与冠心病关系的Meta分析

Meta-Analysis on the Association of TaqIB Polymorphism of Cholesteryl Ester Transfer Protein Gene and Coronary Artery Disease in Chinese Population

目的对中国人胆固醇酯转运蛋白TaqIB基因多态性与冠心病关系进行Meta分析。方法通过中国生物医学文献数据库、中国学术期刊全文数据库和Medline等文献检索途径,全面检索2005年12月31日以前发表的有关中国人胆固醇酯转运蛋白TaqIB基因多态性与冠心病关系的病例对照研究,由2名独立的研究者根据纳入标准评价筛选合格文献,漏斗图检验入选文献的发表偏倚,分析各研究的异质性并采用相应的数学模型进行数据合并,统计其总的比数比和95%可信区间。采用Meta分析专用软件Review Manager（4.2版）进行统计分析。结果7个研究共1 161名冠心病患者和1 149名对照者被纳入Meta分析,入选研究无明显发表偏倚,研究结果之间无明显异质性（χ^2=3.53,P=0.74）,按Peto固定模型进行数据合并,数据合并后胆固醇酯转运蛋白TaqIB中B1B1基因型与B1B2＋B2B2基因型的比数比为1.34,95%可信区间为1.12-1.60（P=0.002）。结论胆固醇酯转运蛋白基因TaqIB酶切位点多态性与中国人冠心病易感性相关,B1等位基因可能是冠心病的遗传危险因素。

Aim To study the assoeiation of TaqlB polymorphism of the cholesteryl ester transport protein （CETP） gene in Chinese popuhtion via meta analysis. Methods Case-control studies published before 31 Dec. 2005 about the association of CETP genc TaqIB polymorphism and coronary artery disease in Chinese population were searched in three digital databases including CBMdise, CHKD and Medline. All the literatures were evaluated and abstracted based on the defined selection criteria by two indepondent investigatom. Publication bias was tested by funnel plot and the odd ratios of all studies were combined dependent on the result of heterogeneity test among the individual studies. The software Review Manager （ Version 4.2 ） was used for meta analysis. Results Seven studies containing 1 161 patients with coronary artery disease and 1 149 control subjects were analyzed. There was no publication bias in 7 reviewed studies, heterogeneity test of reviewed studies showed that there was no significant statistic differences （ X^2 = 3.53, P = 0.74 ） among the OR of individual studies. The summarized odds ratio of coronary artery disease for BIB1 genctype versus BIB2 and B2B2 genotypes across aU7 studies was 1.34 （95% Ca： 1.12- 1.60, P=0.002）. Conclusion In Chinese Han nationality, theTaqIBpolymorphisminCgI＇Pgeneisassoeiatedwithsus- cepfibility of coronary artery disease and the alhle B1 might be a genetic risk factor for coronary artery disease.