5-羟色胺转运体基因多态性与青少年抑郁症的关联研究

Association between polymorphism of serotonin transporter gene and adolescent depression

目的探讨中国汉族青少年抑郁症与5-羟色胺转运体(5-HTT)基因的启动子区多态(5-HTTLPR)之间的关系。方法应用聚合酶链式反应(PCR)扩增技术对84例青少年抑郁症患者和85例健康者进行基因型分析。结果5-HTTLPR基因的3种基因型S/S,L/S和L/L在青少年抑郁症组的分布分别为57.1%,36.9%,6.0%;在对照组分别为57.6%,34.1%,8.2%,两组间差异无显著性(P>0.05)。抑郁症组中S/S基因型患者HAMD自杀因子评分明显高于L/L和L/S型患者(P<0.01)。结论5-HTT基因多态性与青少年抑郁症无明显关联。抑郁症中携带S/S基因型患者的自杀风险相对比L/L型、L/S型患者高。

Objective： To explore the association between polymorphism of serotonin transporter gene and major depressive disorder （MDD） in adolescent. Methods： Altogether 84 MDD patients and 85 healthy controls were included in this study. The subjects were genotyped directly with polymerase chain reaction amplification fragment length polymorphism techniques. Results：The difference of genotypes and alleles of 5 - HTTLPR between two groups was not significant （ P 〉 0.05 ）. The difference of genotypes and alleles of 5 - HTTLPR between suicide behavior and major depression disorder in adolescent was not significant（ P 〉 0.05 ）. The scores of suicide - item of HAMD of patients with S/S genotypes were significantly higher than those of patients with L/L and L/S genotypes in MDD group （ P 〈 0.01 ）. Conclusion： The association between the polymorphisms of 5 - HTTLPR and adolescent depression was not significant. The results imply that the depression patients with S/S genotypes are at higher risk of suicide than the patients with L/S or L/S genotypes.