焦虑障碍患者脑部枕区事件相关电位P300的特征

Experimental study of anxiety disorder of event-related potentials P300-Occipital zero in patients with anxiety disorder

目的 探讨焦虑障碍患者脑部枕区事件相关电位P300的特征。方法 对37例焦虑障碍患者和35名健康成年人，应用国产WOND2000C脑诱发电位仪进行P300检测。结果 与正常对照组相比，焦虑障碍组OZ点P3靶潜伏期后移[正常组（328±16）ms，焦虑障碍组（344±19）ms]，P2靶波幅降低[正常组（7．0±1．8）μV，焦虑障碍组（4．2±1．2）μV]，P3靶波幅降低[正常组（6．0±1．9）μV，焦虑障碍组（4．5±2．2）μV]，非靶P2波幅降低[正常组（3．8±0．9）μV，焦虑障碍组（1．7±0．8）μV]。结论 焦虑障碍P300变化与抑郁症呈同一趋势，焦虑障碍P300变化诸特点值得进一步随访。

Objective To study characteristic of event-related potentials P300-Oz in patients with anxiety disorder. Methods With Chinese WOND2000C Instrument, P300 test was carried out in 37 patients with anxiety disorder and 35 healthy adult controls. Results Patients with anxiety disorder had significant delayed P3 latency （NC ：328± 16ms, AN ：344 ± 19ms, t = 3.85, P 〈 0.01 ）, decreased P2 （ NC ：7.0 ± 1.8μ, AN ：4.2± 1.2μV, t =7.81, P〈0.01） and P3 （NC：6.0 ±1.9μV, AN：4.5±2.2μ, t=2.83, P〈0.05） and P2（NC：3.8 ±0.9 μV, AN ： 1.7 ±0.8 μV, t = 9.55, P 〈 0.01 ） amplitude of P300 than those of the controls at Oz. Conclusion The characteristics of P300 of anxiety disorder patients deserve further following up.