莫达芬尼对48h睡眠剥夺军校学员警觉性及心理健康状况的影响

Effects of modafini on alert and mental health of healthy male during 48h of sleep deprivation

目的 探讨新型中枢兴奋性药物莫达芬尼对睡眠剥夺（SD）条件下警觉性及心理健康状况的影响。方法 实验对象为某军队院校18名健康男性学员，随机分为实验组（莫达芬尼组）和对照组（安慰剂组），睡眠剥夺共48h。SD期间进行字母划销测验，记录每分钟正确划销字母数。并在SD前后采用症状自评量表（SCL-90），焦虑自评量表（SAS），抑郁自评量表（SDS）进行心理健康评估。结果 实验组在sD32h、SD44h、SD48h三个时间点的每分钟正确划销字母数（CCNM）显著高于对照组[分别为（52、52±6．13）个VS（45．87±5．68）个；（49．69±5．68）个VS（40．64±4．59）个；（49．53±5．73）个VS（41、74±5．60）个，均P〈0．05]；实验后实验组SCL-90中的躯体化、人际、抑郁、焦虑、SAS总分、SDS总分显著低于对照组。结论 莫达芬尼可以减弱SD不良影响，提高SD下的警觉性；同时维持SD下的心理健康水平。

Objective To explore modafinil on alert and mental health of healthy male during 48h of sleep deprivation. Methods Eighteen cadets with normal sleep wake habits were divided into 2 groups：experimental group （ n = 9） and control group （ n = 9）. The whole experiment was totally 48 hours. Letter cancellation test was given during sleep deprivation;and correct concealing numbers pre minute were recorded. Cadets were assessed with Symptom Checklist 90 （SCL-90） , Self-Rating Anxiety Scale （SAS） , Self-Rating Depression Scale （SDS）. Results Compared with control group, the correct concealing numbers per minute were increased significantly at SD 32h ,SD 44h,SD 48h when sleep was deprived （52.52 ± 6. 13 vs 45.87 ± 5.68 ;49.69 ± 5.68 vs 40.64 ±4.59;49.53 ±5.73 vs41.74 ±5.60,respectively, allP〈0.05）. Conclusion During sleep deprivation, modafini, a new class of psychostimulant, can improve attention and alert,and maintain mood.