西酞普兰治疗抑郁症临床研究

Clinical Study of Citalopram in the Treatment of Depressive Disorder

目的通过对西酞普兰20mg/d治疗抑郁症的疗效、副反应和安全性的研究,探讨最佳治疗方案,提高治愈率。方法使用汉密顿抑郁量表(HAMD)17项版本,对患者入组时的基线值,治疗时第2、4、6周分别进行评分,以评定病情严重度及其变化和疗效,记录副反应和合并用药情况。结果发现本组病例通过西酞普兰20mg/d6周治疗后,有57.7%临床痊愈,3.8%显效,32.7%有效,5.8%改善,其有效率达94.2%。52例患者在西酞普兰治疗中可出现恶心、头痛等副反应。服药治疗6周后大多数患者副反应基本消失。结论西酞普兰是一种安全、高效、耐受性好、副反应小、应用范围广的抗抑郁药,可作为一线抗抑郁药物使用。

Objective To find the best treatment program by studying the effect, side-effect and the security of Citalopram which is administered 20mg/d in curing depressive disorder. Methods HAMD version 17 is used to evaluate the basic state, 2 weeks, 4 weeks, 6 weeks after Citalopram were given. The severity and the change of the disease, the curative effect were compared. Side effect and combined medicine were recorded. Results 57.7% recovery rate were recorded after Citalopram were used for 6 weeks, 3.8% were excellent, 32. 7% were effective, 5.8% were amended, total effective rate reach to 94. 2%. Nausea （40.4%）, headache（17.3%）, lethargy（15.4%）, perspiration increment （5.8%）, dry mouth（5. 8%）, anorexia （5.8%）, constipation（3.8%）, lassitude（3.8%）, dizziness（1.9%） etc were observed in 52 patients. All the side effects which were all unserious have been observed during the 1st-2nd week after Citalopram were used 20mg/d. Most side effects were lighten after 4 weeks and disappeared after 6 weeks. Conclusion Citalopram is a safety and effective antidepressant drug with good toleration, which can be used clinically as the fist choice.