西酞普兰与阿米替林治疗伴有焦虑症状的抑郁症的比较研究

Comparative Study of Citalopram and Maprotiline in Treating Depression Accompanied with Anxiety

目的探讨西酞普兰治疗抑郁症伴焦虑症状的疗效及安全性。方法83例抑郁症病人随机分为2组,西酞普兰组40例,口服西酞普兰20～40mg/d。阿米替林组43例,口服阿米替林从25mg,bid,逐渐增量至150～250mg/d,疗程均为6wk。2组在治疗前及治疗后wk1、2、4、6均以HAMD,HAMA,TESS评定观察。结果对抑郁症状的治疗,西酞普兰组显效率为78%,阿米替林组为75%,差异无显著意义(P>0.05);对伴随的焦虑症状的治疗,西酞普兰组显效率为80%,阿米替林组为63%,差异有显著意义(P<0.05)。西酞普兰组不良反应较阿米替林组少。结论西酞普兰治疗抑郁症伴焦虑症状的疗效肯定,不良反应少,耐受性好,依从性高。

Objective To explore the effect and safety of citalopram in treating depression accompanied with anxiety. Methods 83 patients were randomly devided to citalopram group （43 cases） and maprotiline group（40 cases）, and all patients were evaluated with HAMD,HAMA and TESS before and after therapy. Results There was no significant difference in the therapeutic effect of citalpram and maprotiline in depression. But the therapeutic effects had significant difference between citalopram group and maprotiline group in anxiety. The side-effects of citaiopram group were less than those of maprotiline group. Conclusion The therapeutic effect of citalopram is affirmative in depression and its side-effect is fewer and milder.