1992～2005年玛纳斯县志贺菌菌群分布及耐药性分析

Flora Distribution and Analysis of Drug Resistance of Shigella in Manas County from 1992 to 2005

[目的]探讨玛纳斯县细菌性痢疾病原菌志贺菌的菌群、菌型分布及耐药状况，以制定科学有效的防治对策。[方法]对1992～2005年玛纳斯县检出的149株志贺菌有关资料进行分析。[结果]149株志贺菌中，福氏（B群）占69．80％，痢疾志贺菌（A群）占13．42％，宋内氏（D群）占12．75％，鲍氏（C群）占4．03％，B／D为5．47，不同时期分离的菌均以B群为主，A群次之，D群和C群分列第3、4位；B群2a、1b分别占36．91％、8．72％，Al型和宋内氏菌分别占11．41％、12．75％。检测87株菌，对氨苄青霉素、四环素、复方新诺明、利福平、氯霉素、庆大霉素、氟哌酸、头孢呋辛、痢特灵的耐药率分别为95．40％、98．85％、95．40％、97．70％、60．92％、16．09％、26．44％、10．34％、14．94％。[结论]玛纳斯县志贺氏菌的主要流行菌为B群（以2a为主），菌株对常用抗菌药物的耐药性较严重。

[Objective]To work out the scientific and efficient preventive measures after the investigation on the distribution of flora population,bacterial type,and status of drug resistance of pathogenic bacteria of shigella of bacillary dysentery. [Methods]Data analysis of 149 strains of Shigella detected in Manas County from 1992 to 2005 was conducted. [Results]Of the 149 strains of Shigella,Sh. Flexneri （Group B） accounted for 69.80%, Sh. Dysenteriae（Group A） 13.42 %, Sh, Sonnet（Group D） 12.75 % ,Sh. Boydii （Group C） 4.03 %, and B/D 5.47. Group B is the majority of the bacteria separated in different periods, then came Group A, Group D and Group C; 2a, lb of Group B accounted for 36.91% and 8.72% ,A1 type and Sh. Sonnet accounted for 11.41% and 12.75% respectively. 87 strains of Shigellae have been tested to be drug-resistant toward Ampicillin,Tetracycline, TMP-SMZ, Rifamicin, Chloramphenicol, Gentamicin, Norfloacin, Cefuroxime, and Furazolidone with the respective resistance percentage of 95.40%, 98.85%, 95.40 %, 97.70%, 60. 92 %, 16.09 %, 26.44 %, 10.34 %, and 14. 94 %. [Conclusion] The prevalent bacteria of Shigellae in Manas County are Group B （mainly 2a）,which has comparatively high drug resistance toward the antiseptic medicine that most in use.