氟西汀联合心理干预治疗抑郁障碍临床研究

A clinical study of fluoxetine combined with psychological intervention in treatment of depressive disorder

目的探讨氟西汀联合心理干预治疗抑郁障碍的临床疗效。方法将62例抑郁障碍患者随机分为研究组32例,对照组30例。两组均给予氟西汀治疗。在药物治疗的基础上,研究组联合心理治疗。8w疗程结束后,两组均进行门诊随访1次.mo-1,共6mo,观察复发情况。治疗前与治疗第8w末采用汉密顿抑郁量表、汉密顿焦虑量表评定临床疗效。结果治疗8w末研究组总有效率93.75%,对照组73.33%,两组间比较差异有显著性(χ2=4.77,P<0.05);两组治疗8w末汉密顿抑郁量表、汉密顿焦虑量表评分均较治疗前有极显著性下降(P<0.01),研究组较对照组下降更显著(P<0.01)。随访6mo末研究组复发率显著低于对照组(χ2=6.67,P<0.01)。结论氟西汀联合心理干预治疗抑郁障碍较单纯药物治疗疗效显著。

Objective To explore the curative effect of floxetine combined with psychological intervention in depressive disorder. Methods Hamilton Depression Rating Scale （HAMD） and Hamilton Anxiety Rating Scale （HAMA） were carried out in 62 patients with depressive disorder. They were divided randomly into 2 groups： the study group （n=32） received both floxetine and psychotherapy, while the control group （n = 30） only received drug therapy. After 8 weeks, the therapeutic effects were evaluated. Results Compared with pro-treatment, significant difference was found in both groups post-treatment （P〈0.01）. The levels of anxiety and depression were reduced. The scores of HAMD and HAMA in the study group were significantly lower than those in the control group （P〈0.01）. After 8 weeks of treatment, the total effective rate of the study group was higher than that of the control group （P〈0.05）. The recurrence rate of study group was obvious lower than that of control group at the 6 months of follow-up. Conclusion Psychological intervention combined with drug therapy is more effective than simple drug therapy in depressive disorder.