雌激素防治阿尔茨海默病的作用机制

Mechanisms of preventing and curing Alzheimer's disease with estrogen

目的:研究雌激素防治阿尔茨海默病(AD)的作用机制。方法:对国内外近年文献进行复习和综述。结果:雌激素能对抗β淀粉蛋白的沉积和毒性作用、促进胆碱能神经元的存活和突触可塑性、抗氧化和维持神经元的钙稳态、调节载脂蛋白E的表达、减轻炎症反应、增加脑血流量和脑的能量代谢,从而影响AD的发生、发展。结论:雌激素可通过多条途径影响AD的发生、发展,雌激素替代治疗对于防治AD具有重要作用。

Objective： To study the mechanisms of preventing or curing Alzheimer＇s disease with estrogen. Methods： Related documents published recently were reviewed and summarized. Results： Estrogen can antagonize deposition and toxicity of β-amyloid, enhance survival of cholinergic neurons and synaptic plasticity, antagonize oxidation and maintain calcium homeostasis, regulate apolipoprotein-E expression, decrease inflammation, increase cerebral blood circulation and glucose metabolism, so as to interfere genesis and development of Alzheimer＇s disease. Conclusion： Estrogen can influence genesis and development of Alzheimer＇s disease in various ways. Estrogen replacement therapy has significant effects on preventing and curing of Alzheimer＇s disease.