白色念珠菌基因组研究进展

Progress on genome of Candida Albicans

目的:介绍白色念珠菌基因组的最新研究进展。方法:查阅国内外大量关于白色念珠菌基因组研究的文献并进行综合详述。结果:白色念珠菌是第一个完成全基因组测序的致病性真核生物,在基因组序列信息研究上取得了重大进展,在基因功能、转录组、蛋白质组等方面获得了许多重要成果。结论:白色念珠菌的基因组研究成果将对研究白色念珠菌的致病机制、耐药机制以及抗真菌药物开发有重大的意义。

Objective： To introduce the recent progress on the genome of Candida albicans. Methods： Related literatures on the genome of Candida albicans are reviewed. Results： The genome of Candida albicans was completely sequenced and resulted in an unique data resource representing the first complete set of pathogenic genes from an eukaryotic organism. Great advances were acquired in the studies of its genome sequence information. In addition, many important results were gotten in gene functions, transcriptome, proteome, etc. Conclusion： These achievements will have a significant role in the studies of the virulence, drug resistance mechanism and development of anti-fungal medicine in Candida albicans.