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聚乙烯亚胺衍生物作为非病毒基因载体的研究进展 被引量：1

Progress of Polyethylenimine Derivates Used as Non-viral Gene Vectors
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摘要 综述了通过结构修饰获得的各类聚乙烯亚胺(PEI)衍生物,如PEG修饰、小分子PEI共聚、连接配体或其它高分子骨架物等,及其在基因转染和细胞毒性方面的研究进展。 The progress of several varieties of polyethylenimine （PEI） derivates obtained by structure modification such as PEGylation, graft copolymerization of low molecular weight PEI and chemical conjugation of ligands or macromolecular compounds, with the investigation of gene transfection and cytotoxicity are reviewed.
作者 姚懿 吴飞 金拓
机构地区 上海交通大学药学院
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2007年第5期387-390,共4页 Chinese Journal of Pharmaceuticals
关键词 聚乙烯亚胺 非病毒基因载体 结构修饰 衍生物 综述 polyethylenimine non-viral gene vector structure modification derivate review
分类号 R978.5 [医药卫生—药品]
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  • 1Nukazono K，Hepatology，1996年，23卷，1297页
  • 2Wu G Y，J Biol Chem，1991年，266卷，14338页
  • 3El-Aneed A. An overview of current delivery systems in cancer gene therapy [J]. J Control Release, 2004, 94 (1):1-14.
  • 4Zhao X B, Lee R J. Tumor-selective targeted delivery of genes and antisense oligodeoxyribonucleotides via the folate receptor [J]. Adv Drug Del Rev, 2004,56(8): 1193-1204.
  • 5Nishikawa M, Huang L. Nonviral vectors in the new millennium: delivery barriers in gene transfer [J]. Hum Gene Ther, 2001,12(8) :861.
  • 6Ueno N T, Bartholomeusz C, Xia W, et al. Systemic gene therapy in human xenograft tumor models by liposomal delivery of the E1A gene [J]. Cancer Res, 2002,62(22):6712.
  • 7Seville P C, Kellaway I W, Birchall J C. Preparation of dry powder dispersions for non-viral gene delivery by freezedrying and spray-drying [J]. J Gene Med, 2002,4(4): 428.
  • 8Arangoa MA, Duzgunes N, Tros de Ilarduya C. Increased receptor-mediated gene delivery to the liver by protamine-enhancedasialofetuin- lipoplexes [J]. Gene Ther, 2003,10(1): 5.
  • 9Koch S, Pohl P, Cobet U, et al. Ultrasound enhancement of liposome-mediated cell transfection on is caused by cavitation effects [J]. Ultrasound Med Biol, 2000,26(5): 897.
  • 10HuntKK, VorburgerSA. Gene Therapy: Hurdles and Hopes for Cancer Treatment [J]. Science,2002,297(5580) :415.

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  • 1谢民强,陈帅君,徐雪青,李仲汉,沈辉,许家瑞.两种顺铂磁性纳米颗粒制备及其特性的比较[J].科学通报,2005,50(19):2079-2084. 被引量：3
  • 2Chua DT, Ma J, Sham JS, Mai HQ, Choy DT, Hong MH, et al. Long-term survival after cisplatin-based induction chemotherapy and radiotherapy for nasopharyngeal carcinoma: A pooled data analysis of two phase III trials. J Clin Oncol 2005; 23(6): 1118- 24.
  • 3Walther W, Schlag PM. Current status of gene therapy for cancer. Curt Opin Onco12013; 25(6): 659-64.
  • 4Zhu B, Zhang P, Zeng P, Huang Z, Dong TF, Gui YK, et al. Tissue factor pathway inhibitor-2 silencing promotes hepato- cellular carcinoma cell invasion in vitro. Anat Rec (Hoboken) 2013; 296(11): 1708-16.
  • 5Xu C, Wang H, He H, Zheng F, Chen Y, Zhang J, et al. Low expression of TFPI-2 associated with poor survival outcome in patients with breast cancer. BMC Cancer 2013; 13(15): 118.
  • 6Wang S, Xiao X, Zhou X, Huang T, Du C, Yu N, et al. TFPI-2 is a putative tumor suppressor gene frequently inactivated by promoter hypermethylation in nasopharyngeal carcinoma. BMC Cancer 2010; 10(9): 617.
  • 7Lavergne M, Jourdan ML, Blechet C, Guyetant S, Pape AL, Heuze-Vourc'h N, et al. Beneficial role of overexpression of TFPI-2 on tumour progression in human small cell lung cancer.FEBS Open Bio 2013; 27(3): 291-301.
  • 8Lai YH, He RY, Chou JL, Chan MW, Li YF, Tai CK. Promoter hypermethylation and silencing of tissue factor pathway inhibitor-2 in oral squamous cell carcinoma. J Transl Med 2014; 12(1): 237.
  • 9Hasson H, Warshawsky A. High-performance liquid chromato- graphic determination of cis-diamminedichloroplatinum(11) (cisplatin) as the o-phenylenediamine complex. J Chromatogr 1990; 530 (1): 219-21.
  • 10Greish K. Enhanced permeability and retention of macromolecular drugs in solid tumors: A royal gate for targeted anticancer nanomedicines. J Drug Target 2007; 15 (7/8): 457-64.

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中国医药工业杂志
2007年 第5期

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