JAKs—STATs信号转导通路与疼痛敏化调控研究进展

JAKs-STATs Signal Transduction Pathway and Pain Hypersensitivity

最近研究表明酪氨酸激酶-信号传导子与转录激活子（Janus kinase—signal transducers and activators of transcription．JAKs-STATs）信号传导通路在疼痛高敏感性的产生和维持中发挥重要作用，但其间的精确机制尚不清。本文综述了JAKs—STATs信号转导通路与疼痛敏化调控方面的研究进展。

Recent studies reveal that Janus kinase-signal transducers and activators of transcription （JAKs-STATs） signaling pathway may play a key role in the induction and maintenance of pain hypersensitivity, but their precise mechanisms are unclear. The molecular mechanisms between JAKs-STATs signal transduction pathway and pain hypersensitivity will be reviewed in this article.