摘要
目的:观察降脂颗粒对非酒精性脂肪肝大鼠模型肝脏脂质的影响。方法:高脂饲料制备SD大鼠非酒精性脂肪肝模型,随机为东宝肝泰组、辛伐他汀组、中药低剂量组、中药中剂量组、中药高剂量组和模型对照组。治疗4周后行肝组织生化和病理学检测。结果:降脂颗粒能明显降低非酒精性脂肪肝大鼠模型肝脂(TG、TC)的水平,改善脂肪变性,降低肝脏炎症反应。结论:降脂颗粒对非酒精性脂肪肝大鼠肝脏脂质和炎症有较好的治疗作用。
Objective ： To investigate the effect of Chinese medicine Jiangzhi Granulas on hepaticlipid of nonalcoholic fatty Liver disease（NAFLD） rat, Methods： The NAFLD SD rat model was established by lfigh fat diet, then divided into six groups at random： Model control group, Dongbaogantai group,Simvastatin group,jiangzhi granlas low-dose group, middle - dose group and high - dose group. Biochemistry of liver tissue and liver specimens were detected respectively after 4 weeks＇ treatment. Results ： jiangzhi granulas can obviously improve hepatitosteatosis, reduce hepaticlipid （ TC, TG） and liver inflammatory reaction of NAFLD ;at model. Conclusion： jiangzhi granulas have a better therapeutical effect on hepaticlipid and inflammation of NAFLD rat model.
出处
《中华中医药学刊》
CAS
2007年第5期942-944,共3页
Chinese Archives of Traditional Chinese Medicine
基金
上海市中药现代化专项资助项目(05DZ19702-4)
关键词
降脂颗粒
非酒精性脂肪肝
肝脏脂质
Jiangzhi granula
nonalcoholic fatty liver（NAFLD）
hepaticlipid
