丹参透皮吸收影响因素的初步研究

Preliminary Study on Transdermal Absorption Factors Affecting of Salvia Miltiorrhiza Bge

目的:对丹参透皮特性进行研究,探讨影响中药有效成分透皮吸收的主要因素。方法:以丹酚酸B为指标性成分,采用体外Franz扩散池法进行体外透皮吸收实验;采用高效液相色谱法对体外透皮吸收实验接收液中的丹酚酸B进行含量测定。结果:丹酚酸B经不同动物皮肤具有不同的透皮吸收;3%氮酮+2%薄荷脑合用时促渗效果更优;生理盐水为接受液透过率最大,酸水为接受液透过量最少。结论:丹酚酸B体外透皮吸收良好。

Objective： To study transdermal absorption peculiarity of Salvianolie acid B in vitro. Methods： Drug permeation tests were performed through excised skin in Franze diffusion cell. Salvianolie acid B concentration insample was determined by reversedphase high performance liquid chromatography（HPLC）. Results： The transdermal absorption of different medicine is different, The compound penetration enhancer consisting of 1 -menthol（2% ） and Azone（3% ） had a prominent promotion action on absorption of Salvianolie acid B. the water and NaCL（0,.9% ） as receiving liquid effect on transdermal pernetration of Salvianolie acid B is better than acid water. Conclusion： The transdermal dilivery of Xuandan babugao is good.