摘要
The syntheses of three naturally occurring diphyllin glycosides have been achieved. 7-O-β-D-Qtfmovopyranosyldiphyllin （patentiflorin A） and 7-O-β-L-fucopyranosyldiphyllin （patentiflorin B） were synthesized by the glycosylation of diphyllin with peracetylglycosyl bromides under phase transfer catalysis （PTC） conditions. 4＂-O-Acetyl-7-O-β-L-fucopyranosyldiphyllin （4＂-O-acetyl patentiflorin B） was obtained from patentiflorin B on an orthoesterification-orthoester rearrangement approach. Their ^1H NMR, ^13C NMR and HRMS signals are all consistent with those reported for the natural product.
The syntheses of three naturally occurring diphyllin glycosides have been achieved. 7-O-β-D-Qtfmovopyranosyldiphyllin （patentiflorin A） and 7-O-β-L-fucopyranosyldiphyllin （patentiflorin B） were synthesized by the glycosylation of diphyllin with peracetylglycosyl bromides under phase transfer catalysis （PTC） conditions. 4＂-O-Acetyl-7-O-β-L-fucopyranosyldiphyllin （4＂-O-acetyl patentiflorin B） was obtained from patentiflorin B on an orthoesterification-orthoester rearrangement approach. Their ^1H NMR, ^13C NMR and HRMS signals are all consistent with those reported for the natural product.
基金
Project supported by the National Natural Science Foundation of China （No. 30400564）.
