择期经腹腔镜胆囊切除术预防性应用抗生素必要性的探讨

Necessity of prophylactic antibiotics use in patients undergoing elective laparoscopic cholecystectomy

目的探讨在择期腹腔镜胆囊切除术中预防性使用抗生素的必要性。方法选择择期行腹腔镜胆囊切除术的感染低危患者200例,随机分为A组(100例)和B组(100例)。A组于术前30min及术后1h各用一次抗生素;B组手术前后均不使用抗生素。每例患者通过临床观察,门诊或电话随访,观察其术后1个月感染性并发症的发生率。结果共发生感染并发症4例(2.00%),其中A组2例,分别为戳孔感染1例、尿路感染1例;B组2例(2.00%),分别为戳孔1例,肺部感染1例,经χ2检验,两组感染发生率差异无统计学意义(χ2=0.00,P>0.05)。结论择期腹腔镜胆囊切除术中,对于感染低危患者可以不预防性使用抗生素。

Objective To investigate the necessity of prophylactic administration of antibiotics in patients undergoing elective LC. Methods Two hundred patients with the low risk in postoperative infection were randomized into two groups to receive single dose antibiotics at 0.5 hour before LC and 1 hour after the operation （group A ） or no prophylactic intiblotics （group B）. The incidence of postoperative infection was compared between the two groups one month later in the bllow - up. Results The incidences of postoperative infection were both 2.00% （2/ 100） in group A and group B. There was no statistics significance between two groups. Conclusion It is unnecessary for the patients undergoing elective LC with low risk in postoperative infection to administrate prophylactic antibiotics.