高血压药物治疗对中年男性性功能的影响

Effect of the anti - hypertensive medications on the middle - age men＇ s sexual function

目的研究五种常用降压药物对中年男性性功能的影响。方法250例高血压病人随机分为五组，分别应用氢氯噻嗪、倍他乐克、硝苯地平缓释片、依那普利和缬沙坦给予治疗。所有病人血压控制达标的同时，应用“男性性功能问卷”分别在4、8、16、24、28周末各进行一次性功能调查评估。结果氢氯噻嗪、倍他乐克和硝苯地平缓释片对性功能有不利的影响（P〈0．01或P〈0．05），依那普利对性功能无明显影响，缬沙坦对性功能有正面影响。结论氢氯噻嗪、倍他乐克和硝苯地平缓释片对于中年男性高血压病人的性功能有不利的影响，依那普利对性功能无明显影响，缬沙坦对性功能有正面影响。

Objective To observe the effect of five kinds of anti -hypertensive medications on the middle - age men＇ s sexual function. Methods Two hundred and fifty essential hypertension patients were divided into five groups randomly. Patients of Hyd group received hydrochlorothiazide. Bet group received betaxolol. Nil - SR group were given SR nifedipin. Ena group were given enalapril and valsartan were given to val group. All patients＇ blood pressure had been controlled. The treatment persisted for twenty - eight weeks. Sexual function were evaluated by brief male sexual function inventory for Urology O＇ Leary 1995 at the 4 ,8 , 16 ,24,28 weekends. Results The worst effect on sexual function was found in Bet group ; hydrochlorothiazide and SR nifedipin had some negative effects （ P 〈 0.01 or 0.05 ） . Enalapril was shown no effect on sexual function. Valsartan could distinctively improve men＇ s sexual function. Conclusion Some kinds of anti - hypertensive medicine have negative effect on meng sexual function. Betaxolol , hydrochlorothiazide and SR nifedipin seem to have the significant worse adverse effect , while enalapril have no notable side effect. Valsartan appears to have positive effect on sexual function.