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神经酰胺及代谢关键酶与肿瘤的多药耐药 被引量：1

Ceramide Metabolism and Its Relationship with Multidrug Resistance of Tumors
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摘要 多药耐药(multidrug resistence,MDR)是肿瘤化疗失败的主要原因,多年来学者一直致力于多药耐药机制的研究。神经酰胺作为细胞凋亡的第二信使,参与多种细胞凋亡,它与凋亡相关因子bcl-2、NF-κB的关系一直是研究的重点。葡萄糖神经酰胺合成酶(glucosylceramide synthase,GCS)可催化神经酰胺糖基化使其转变为葡萄糖神经酰胺,许多研究证明GCS与MDR表型有关。 Multidrug resistance is considered to be the main obstacle to the effective chemotherapeutics, which has been investigated for years in the medical field. Ceramide functions as a second messenger to several signaling pathways, and the relationship between it and bcl-2 or NF-r,B has always been emphasized. Glucosylceramide synthase（GCS）catalyzes the glycosylation and inactivation of ceramide to glucosylceramide, which has been proved to be responsible for MDR phenotype.
作者 胡萍萍 田波 陈同钰
机构地区 苏州大学附属第三医院病理科
出处 《食品与药品》 CAS 2007年第05A期46-49,共4页 Food and Drug
关键词 多药抗药性 神经酰胺 BCL-2 NF-ΚB 葡糖神经酰胺合酶 multidrug resistance ceramide bcl-2 NF-κB glucosylceramide synthase
分类号 R730.2 [医药卫生—肿瘤]
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参考文献22

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二级参考文献5

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共引文献3

同被引文献22

  • 1张涛,李百祥,蔡天德.鞘磷脂的研究进展[J].中国公共卫生,2004,20(1):105-106. 被引量：12
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食品与药品
2007年 第05A期

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