改良口腔护理对急性白血病化疗致口腔粘膜炎的防治

Mucositis Prevention by Improved Dental Care in Acute Leukemia Patients

目的评估改良口腔护理对急性白血病化疗患者口腔并发症的防治效果。方法34例白血病患者随机分为改良口腔护理组和常规口腔护理组。在化疗前后不同时间对患者检查口腔及牙齿情况,寻找潜在感染病灶。在化疗第1、7、14、21、28 d用牙龈指数评价牙周状态。结果改良口腔护理组牙龈指数、口腔并发症均明显低于常规护理组。结论改良口腔护理对急性白血病化疗口腔并发症有一定的防治作用,值得进一步推广与改进。

Objective The aim of the present study was to evaluate the effects of the intensive dental care protocol in preventing oral complications in acute leukemia patients. Methods Thirty -four patients hospitalized for induction remission therapy for acute leukemia were randomly assigned to one of two groups, whether to receive intensive dental care protocol or not. The intensive dental care group of patients received dental treatment and plaque and calculus removal prior to chemotherapy and supervised oral hygiene measures during chemotherapy. The limited dental care group of patients did not receive prechemotherapy dental care. Groups were comparable in age, sex, and antineoplastic treatment received. Patients were examined after admission to the hospital; at the initiation of the chemotherapy; and 7, 14, 21, and 28 days after initiation of therapy. Positive data about subjective difficulties were taken by anamnesis. gingival index （GI） were used to assess the periodontal status of the patients. Results The re- suits of this study pointed out lower mean values of GI in the intensive dental care group of patients during the whole period of examination. Although the differences in mean values were not statistically significant on most of the examination days, intensive dental care group of patients developed less severe and less painful oral complications compared to the limited dental care group of patients. Conclusion We conclude that proper dental care and preventive measures both before and during chemotherapy can be beneficial to these patients