紫苏梗对大鼠离体结肠肌条收缩运动的影响

Effect of Perilla Frutescens Stem on contractile activity of isolated colon smooth muscle strips in rats

[目的]观察紫苏梗水提液对正常及肢体缺血-再灌注大鼠结肠环形肌条收缩波平均振幅和张力的影响。[方法]利用肢体缺血-再灌注大鼠制备胃肠动力障碍(FD)模型。取大鼠结肠环形肌条,置于恒温灌流肌槽内,通过多导生理记录仪记录紫苏梗在结肠环形肌条收缩活动中的作用。[结果]紫苏梗水提液能升高FD模型大鼠结肠环形肌条收缩波平均振幅、降低结肠张力,对正常大鼠则无明显影响。[结论]紫苏梗水提液对FD模型大鼠结肠环形肌条收缩运动具有明显兴奋作用,而对正常大鼠结肠收缩运动无兴奋作用。

[Objective] To study the effect of Perilla frutescens stem on the contractile activity of isolated colon smooth muscle strips in rats. [Methods] Functional dyspepsia（FD） model was induced in lower limb in ischemia and reperfusion rats（LIR）. The circular muscle strips of rat colon were suspended in a thermostat pool for perfusion. The average contractile amplitude and the resting tension of colonic muscle strips were recorded. [Results] Perilla frutescens stem could increase the average contractile amplitude of colonic muscle strips in FD rats and decrease the resting tension. But it was no use for normal rats. [Conclusions] The results indicate that Perilla frutescens stem has significant exciting action on contractile activity of isolated colonic smooth muscle strips in FD model rats.