单纯性肥胖者饮水负荷试验与胃感觉

Water loading test and gastric sensation in simple obese people

目的探讨单纯性肥胖者饮水负荷试验与胃感觉的关系。方法采用饮水负荷试验,对53例单纯性肥胖症志愿者和32例正常体重健康志愿者进行胃可耐受容量检测,并与电子恒压器进行胃底机械性扩张检测结果相比较,观察肥胖者胃感觉功能变化。结果(1)饮水负荷试验测定结果:肥胖者初始饱感时饮水容量和最大耐受饮水容量分别为(833±225)ml和(1592±217)ml,较正常体重组[(566±136)ml和(1000±236)ml]显著增多(P<0.01)。(2)电子恒压器检测结果:肥胖组初始饱感时气囊内容积和最大耐受时气囊内容积分别为(459±75)ml和(792±262)ml,较正常体重组[(263±127)ml和(500±156)ml]显著增大(P<0.01)。(3)肥胖组初始饱感时胃内压、最大耐受时胃内压分别为(9.2±4.0)mmHg和(10.4±3.3)mmHg,与正常体重组[(9.3±1.9)mmHg和(10.5±2.8)mmHg]相比无显著性差异,P>0.05。结论胃可耐受容积增大,内脏敏感性降低,饱感延迟发生,可能是单纯性肥胖者肥胖形成的主要原因,饮水负荷试验可作为非侵入性方法判定单纯性肥胖者胃感觉功能的有效指标。

Objective To investigate the relationship between water loading test and gastric sensation in simple obese people.Methods 53 obese volunteers and 32 non-obese healthy volunteers were studied by water loading test and Barostat test. Gastric sensation change （initial satiety, maximal tolerance） was observed. Results （ 1 ） Water loading test： the drinking water volme at initial satiety and maximal tolerance was （833 ± 225）ml and （ 1 592 ± 217） ml in obese group, which was significantly larger than that in non-obese group [ （566 ± 136）ml and （1 000 ± 236）ml, P 〈0.01 ]. （2）Barostat test：the bloon volume at initial satiety and maximal tolerance was （459 ± 75）ml and （792 ± 262）ml respectively, which were significantly larger than those in control group[ （263 ± 127）ml and （500 ± 156）ml, P 〈0.01 ]. （3）The initial intragastric pressure and the maximal tolerance pressure were （9.2 ± 4.0）mm Hg and （ 10.4 ± 3.3）Iron Hg respectively in obese group, which were similar to those of control group[ （9.3 ± 1.9）mm Hg and （10.5 ±2.8）mm Hg, P 〉 0.05].Conclusion Enlargement of gastric capacity,decrease of viseeral sensitivity and delay of satiety occurrence may be the main mechanisms of obesity; water loading test is a non-invasive and effective assay to evaluate gastric sensation in obese simple people.