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缺血后处理对缺血再灌心肌保护作用的研究进展 被引量：4

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摘要 20世纪80年代开始的溶栓治疗以及90年代以来兴起的经皮冠状动脉介入治疗（PCI）技术，是急性心肌梗死治疗史上里程碑式的进步。然而随之带来的再灌注心律失常、心肌舒缩功能障碍、代谢异常及心肌超微结构的改变，即心肌的缺血再灌注损伤，直接影响到患者的预后，因此，如何防止缺血／再灌注损伤已成为现今研究的重要内容。
作者 顾迎春 于晓玲 刘叶 唐博
机构地区 辽宁医学院附属第一医院心内科 辽宁医学院附属第一医院高级诊疗中心 辽宁医学院附属第一医院ICU 辽宁医学院附属第一医院药理学实验室
出处 《中国心血管病研究》 CAS 2007年第5期385-387,共3页 Chinese Journal of Cardiovascular Research
关键词 缺血再灌注损伤 心肌保护作用 缺血后处理 经皮冠状动脉介入治疗 缺血/再灌注损伤 再灌注心律失常 急性心肌梗死 心肌超微结构
分类号 R657.3 [医药卫生—外科学]
  • 相关文献

参考文献16

  • 1[1]Murry CE,Jennings RB,Reimer KA.Preconditioning with ischemia:adelay of lethal cell injury in ischemi cmyocardium.Circulation,1986,74:1124-1136.
  • 2[2]Zhao ZQ,Corvera JS,Ilalkos ME,et al.Inhibition of myocardial injury by ischernic postconditioning during reperfusion;comparision with ischemic preconditioning.AM J Physiol Heart Circ Physiol,2003,285:H579-H588.
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  • 7[7]Philipp S,Downcy JM,Cohen MV.Postconditioninn must he initiated in less than 1 minute following reperfusion and is dependent on adenosine receptors and P13-kinase.Circulation,2004,110(Suppl Ⅲ):S163.
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二级参考文献21

  • 1Nakano A,Liu GS,Heusch G,et al.Exogenous nitric oxide can trigger a preconditioned state through a free radical mechanism,but endogenous nitric oxide is not a trigger of classical ischemic precoditioning[J].J Mol Cell Cardiol,2000,32:1 159-1 167.
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  • 9肖献忠，中国病理生理杂志，1995年，11卷，741页
  • 10Mestril R，J Clin Invest，1994年，93卷，759页

共引文献40

同被引文献10

引证文献4

二级引证文献9

中国心血管病研究
2007年 第5期

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