清开灵合生脉注射液治疗急性酒精中毒30例

Clinical Observation of Qingkailing Combined with Shengmai Injection in Treating 30 Cases of Acute Alcohol Intoxication

目的:探讨中药清开灵合生脉注射液治疗急性酒精中毒(AAI)的机制。方法:将符合入选标准的90例随机分清开灵注射液合生脉注射液治疗(治疗组)、纳洛酮治疗(纳洛酮组)、生脉注射液治疗(生脉组)和清开灵治疗(清开灵组),按各组拟定方案进行治疗;记录病例清醒时间、症状缓解时间。治疗前及治疗后的3小时,分别抽取静脉血测定血浆中β-内啡肽(β-EP)、超氧化物歧化酶(SOD)的水平。结果:治疗组与纳洛酮组清醒时间、症状缓解时间差异无显著性意义(P>0.05);该两组与生脉组、清开灵组比较差异均有显著性意义(P<0.01);治疗组与纳洛酮组、生脉组、清开灵组治疗前β-EP、SOD无明显差异(P>0.05),治疗后,治疗组与其他三组血浆β-EP均有下降、SOD均上升。治疗组与纳洛酮组比较,差异无显著性意义(P>0.05);治疗组、纳洛酮组与生脉组、清开灵组比较,差异均有显著性意义(P<0.01)。结论:清开灵合生脉注射液治疗急性酒精中毒具有与纳络酮等同的作用,清开灵合生脉注射液通过降低AAI患者血浆的β-EP及升高SOD水平而取效,临床可两药合用于治疗急性酒精中毒。

Objective：To investigate the mechanism of Qingkailing combined with Shengmai injection in treating acute alcohol intoxication （AAI）. Methods ：90 cases of acute alcoholism were randomly divided into the treatment group （Qingkailing combined with Shengmai injection group） and the contrast groups （ including Naloxone group, Shengmai group and Qingkailing group）. All groups were treated by respective medicine. The time of regaining consciousness and that of alleviating symptom were noted. The level of P-EP and SOD in venous blood plasma were measured before and 3h after treatment. Results：The difference of time of regaining consciousness and alleviating symptom in the treatment group and the Naloxone group had no significant meaning （ P 〉 0.05 ）. While that in the former groups and the shengmai group, the qingkailing group had significant meaning （P 〈 0.01）. The level of β-EP and SOD in the four groups before treatment had no obvious difference （P 〉 0.05）. After treatment the level of P-EP was decreased and that of SOD improved. The difference in the treatment group and the Naloxone group had no obvious meaning （P 〉 0. 05）. The difference in the former groups and the Shengmai group, the Qingkailing group had obvious meaning （P 〈 0.01）. Conclusion： Qingkailing combined with Shengmai injection has same effect as Naloxone in treating AAI. By decreasing the level of β-EP and increasing the level of SOD, Qingkailing combined with Shengmai can be used in the clinical treatment of AAI.