甲状腺乳头状癌侵袭转移与生存素和p53蛋白表达的关系研究

Expression of survivin and p53 protein in relation to invasion and metastasis of papillary thyroid carcinoma

目的探讨甲状腺乳头状癌(PTC)中生存素(survivin)和p53蛋白表达及其意义。方法应用免疫组织化学方法检测46例PTC、20例甲状腺瘤(TA)、20例结节性甲状腺肿(NG)和15例正常甲状腺组织(NT)中survivin和p53蛋白表达。结果在PTC中,survivin和p53表达阳性率分别为69.6%(32/46)和65.2%(30/46)。PTC中survivin和p53阳性表达率显著高于TA、NG和NT(P<0.05)。Survivin和p53表达与PTC的侵袭转移呈显著正相关(P<0.05)。结论Sur-vivin和p53阳性表达与PTC侵袭、转移密切相关,检测survivin和p53蛋白的表达可作为判断PTC生物学行为的参考指标。

Objective To investigate the correlation of the expression of survivin and 1353 proteins with the potentials of invasion and metastasis in papillary thyroid carcinoma （PTC）. Methods Immunohistoehemieal method was used to investigate the expression of survivin and 1353 proteins in 46 eases of PTC,20 cases of thyroid adenoma （TA） ,20 eases of nodular goiter （NG） and 15 cases of normal thyroids （NT）. Results The positive rate of survivin and 1353 in PTC was 69.6 % （32/46） and 65. 2% （30/46） res13eetively,signifieantly higher than in TA,NG and NT （ P 〈0.05）. There was a positive correlation between survivin and 1353 expression and tumor invasive and metastasie potential in PTC （ P 〈 0.05）. Conclusion The expression of survivin and 1353 protein was closely correlated with the invasion and metastasis of PTC. Survivin and 1353 proteins might be considered as biologic behavior indicators for PTC.