摘要
目的探讨结肠癌合并糖尿病患者血管内皮生长因子-C(VEGF-C)表达情况与淋巴转移的关系。方法采用免疫组化PV-9000二步法检测47例结肠癌组织中VEGF-C表达情况。结果结肠癌合并糖尿病患者组VEGF-C阳性表达(78.6%)明显高于无糖尿病组(42.4%)(P<0.05)。VEGF-C阳性表达在结肠癌淋巴结转移组(69.6%)显著高于无淋巴结转移组(37.5%)(P<0.05)。结论糖尿病可能增加结肠癌淋巴转移几率。
Objective To discuss the relationship between VEGF - C expression and lymphatic metastasis on patients with diabetes mellitus and colon cancer. Methods Immunohistoehemistry PV - 9000 two step method was performed to measure the situation of VEGF- C expression in 47 ease of colon cancer tissue. Results VEGF- C positive expression on patients with diabetes mellitus and colon cancer group （78.6 % ） is significantly higher than that without diabetes melfitus group （42.4 % ） （ P〈 0.05 ） ; VEGF - C positive expression in lymphatic metastasis group （69.6 % ） is significantly higher than that without lymphatic metastasis group （37.5 % ） （ P 〈 0.05 ）. Conclusion Diabetes mellitus may increase the probability of lymphatic metastasis and colon cancer.
出处
《临床外科杂志》
2007年第4期247-248,共2页
Journal of Clinical Surgery
关键词
结肠癌
糖尿病
VEGF—C
淋巴转移
colon cancer
diabetes mellitus
vascular endothelial growth factor C
lymphatic metastasis
