干燥综合征肝脏损害临床研究

Primary Sjgren's Syndrome with Liver Involvement

目的探讨原发性干燥综合征(pSS)肝脏损害的发生率、免疫学特点及病理学改变特点。方法对52例pSS临床资料进行回顾性分析。结果肝损害发生率为26.9%,肝损害组与无肝损害组在年龄、性别、发病到确诊时间及ANA、抗SSA、抗SSB、RFI、gG阳性率等方面均无显著性差异(P>0.05),γ-球蛋白升高在两组间具有显著性差异(P<0.05)。肝穿刺活检组织学表现以胆管周围淋巴细胞浸润为主。结论pSS肝脏损害可能与原发性胆汁性肝硬化(PBC)高度相关,对激素及免疫抑制剂敏感,预后较好。

Objective To evaluate the incidence,immunological and pathologic features of liver involvement in primary Sjoegren＇s syndrome. Methods 52 patients with primary Sjoegren＇s syndrome were analysized retrospectively for liver involvement by clinical date. Results 14 patients（26.9%） with liver involvement. The rate of age,sex,course of disease, ANA,anti-SSA,anti-SSB,RF and serum IgG in patients with liver involvement did not show any difference from those without liver involvement （P〉0.05）. In the group of liver involvement, γ-globulin were higer than the group without liver involvement （P〈0.05）. The histopathology of liver is charactered as lymphocyte infiltrating aroud the bile duct. Conclusion Liver involvement in primary Sjoegren＇s syndrome is related to primary biliary cirrhosis （PBC）. The steroid and immunosuppressive drugs have some effects.