复发性自然流产与自然杀伤细胞杀伤活性的关系

Study on the relationship between recurrent spontaneous abortion and the cytotoxic effect of NK cells

①目的探讨复发性自然流产(RSA)的发生与自然杀伤(NK)细胞杀伤活性的关系。②方法采用补体裂解法分离NK细胞,MTT法测定RSA组和正常妊娠组NK细胞杀伤活性,并比较两组NK细胞杀伤活性的差异。③结果RSA组NK细胞杀伤活性高于正常妊娠对照组(P<0.05)。④结论RSA的发生与NK细胞杀伤活性增强有关。

Objective To study the relationship between recurrent spontaneous abortion and the eytotoxie effect of NK cells. Method NK cells were separated with complement degradation method, and then the eytotoxie effects of NK cells in recurrent spontaneous abortion group（RAS） and normal pregnant group were determined by MTT. Result The cytotoxic effects of NK cells in RSA were higher than those in control group （ P 〈 0.05 ）. Conclusion The occurrence of RAS might be related to the enhancement of NK cytotoxic effect.