静脉微泵注射小剂量胺碘酮治疗阵发性房颤的疗效和安全性

Effective and safety of the treatment of transvenous low-dose amiodarone by minipump in patients of paroxysmal atrial fibrillation

目的研究静脉微泵注射小剂量胺碘酮治疗阵发性房颤的疗效和安全性。方法2003年2月～2005年12月到上海市第六人民医院急诊科就诊的阵发性房颤病人153例,比较观察期中胺碘酮治疗组和去乙酰毛花苷治疗组间的复律成功率和不良反应率。结果胺碘酮治疗组的成功率为74.1%,去乙酰毛花苷组的成功率为29.2%,两组间差异有显著性(P<0.05)。两组均未见明显不良反应。结论静脉微泵注射小剂量胺碘酮治疗阵发性房颤是安全而且有效的方法,可以广泛运用于大多数器质性和非器质性心脏病的阵发性房颤病人。

[Objective] To determine the effect and safety of the treatment of transvenous low-dose amiodarone by minipump in patients of paroxysmal atrial fibrillation （PAF）. [Method] 153 PAF patients in the emergency department in the Sixth People＇s hospital of Shanghai were followed up from Feb 2003 to Sep 2005. Conversion and adverse effect rates of PAF were compared in the amiodarone group and the dislanoside group. [Result] The conversion rate of PAF obtained in amiodarone group was 74.1%, and dislanoside group was 29.2%. There was significant difference between the two groups （P 〈0.05）. There was obvious adverse effect neither. [Conclusion] The treatment of transvenous low-dose amiodarone by minipump in organic heart disease or non-organic heart disease patients of PAF is effective and safe.