预激方案与标准化疗方案治疗老年急性髓系白血病的比较观察

A comparative observation of CAG regiment and standard chemical therapy regiment in elderly patients with acute myeloid leukemia

目的比较预激方案(CAG方案)与标准化疗方案(DA方案)对老年急性髓系白血病的疗效和不良反应。方法共选择老年急性髓系白血病患者45例,20例使用CAG方案,25例选用DA方案。结果CAG组与标准化疗组对比完全缓解率、有效率差异无显著性(P>0.05),CAG方案组骨髓恢复时间缩短,输血量少,化疗相关死亡率低(P<0.05)。结论对于老年急性髓系白血病,CAG方案疗效肯定、安全。

[Objective] To compare the efficacy and tolerance of CAG regiment and standard chemical therapy （IDA regiment） in elderly patients with acute myeloid leukemia. [Methods] Forty-five elderly patients with acute myeloid leukemia were entered into this study. Twenty patients were administered with CAG regiment; Twenty-five patients were administered with DA regiment. [Results] There were no significant difference in complete remission （CR） and overall response rate between CAG group and DA group. But the recovery time of bone marrow in CAG group was shorter, the volume of blood transfusion was less, the chemical therapy associated mortality rate was lower. [Conclusion] The CAG regiment has promising effect in the treatment of elderly patients with acute myeloid leukemia with mild adverse effect.