加味四逆散对酒精性肝病患者肿瘤坏死因子-α、白细胞介素-6的影响

Effect of Jiawei Sinisan on Serum TNF-αand IL-6 in Patients of Alcohol Liver Diseases

目的研究加味四逆散治疗酒精性肝病(ALD)的疗效及作用机制。方法以小柴胡颗粒作对照,观察对ALD患者治疗前后的症状、体征、谷丙转氨酶(ALT)、谷草转氨酶(AST)、肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)的变化。结果加味四逆散可明显改善患者的症状和体征,显著降低ALT、AST及TNF-α、IL-6水平,总疗效优于小柴胡颗粒。结论加味四逆散对ALD有良好的治疗效果,其通过抗细胞因子TNF-α、IL-6的损伤发挥作用。

Objective To study the mechanism of Jiawei Sinisan （JWSNS） in treating alcohol liver diseases （ALD）. Metheds 80 cases of alcohol liver diseases patients were divided into therapy group （with JWSNS） and control group （with Xiaochaihu granules）. To observe the changes of symptom, physical sign, ALT, AST, and TNF-α, IL-6 as well before and after therapy respectively. Results JWSNS improved patient＇s symptom and physical sign, decreased the levels of ALT, AST, TNF-α, IL-6 obviously. Its curative effect was better than Xiaochaihu granules.Conclusions JWSNS has a good curative effect on alcohol liver diseases through resisting hepatic damage from cellular agents TNF-α and IL-6.