丹蛭降糖胶囊对2型糖尿病胰岛素抵抗模型大鼠血脂的影响

Effect of Danzhi Jiangtang Capsule on the Level of Blood Fat in Model Rats of Type 2 Diabetes Insuling Resistance

目的观察具有益气养阴活血功效的丹蛭降糖胶囊对2型糖尿病胰岛素抵抗模型大鼠血脂的影响。方法采用高热量饲料加小剂量腹腔注射链脲佐菌素(STZ)方法建立类似于2型糖尿病胰岛素抵抗的大鼠模型并分5组,测定各组大鼠治疗后的血糖、胰岛素、胰岛素敏感指数、血脂、血清游离脂肪酸(FFA)水平。结果丹蛭降糖胶囊可以降低2型糖尿病胰岛素抵抗模型大鼠的血脂。结论丹蛭降糖胶囊对2型糖尿病胰岛素抵抗大鼠血脂具有一定的改善作用。

Objective To investigate the effect of Danzhijiangtang capsule on serum fat in type 2 diabetic rats. Metheds The model of type 2 diabetes mellitus rats were established by injecting small does streptozotocin （STZ） into abdomen and feeding high sucrose-fat diet. All the rats were divided randomly into five groups. The level of blood glucose, serum insulin, insulin sensitivity index, blood fat （triglyceride, cholesterol, high-density lipoprotein, low-density lipoprotein）, free fatty acid after treated were examined. Results Danzhijiangtang capsule could decrease the level of blood fat. Conclusions Danzhijiangtang capsule could improve the blood fat in type 2 diabetic rats.