氟比洛酚酯超前镇痛对腹腔镜胆囊切除术后镇痛效果的影响

The preemptive analgesic effect of flurbiprofen axetil injection in patients undergoing laparoscopic cholecystectomy

目的观察氟比洛酚酯超前镇痛对腹腔镜胆囊切除术后镇痛效果的影响。方法选择ASAⅠ或Ⅱ级择期行腹腔镜胆囊切除术患者60例,随机均分为氟比洛酚酯超前镇痛组(A组)、氯诺昔康超前镇痛组(B组)和氟比洛酚酯术后镇痛组(C组)。A组于气管插管前静注氟比洛酚酯50mg;B组于气管插管前静注氯诺昔康8mg;C组于手术结束时静注氟比洛酚酯50mg。用视觉模拟评分(VAS)评定术后0、1、4、8和12h的疼痛程度及术后24h总体镇痛评价。记录患者追加镇痛药和出现不良反应的情况。结果除12h外术后VAS各时点C组均高于A、B组,术后0hVASB组显著高于A组(P<0.05);术后24h总体VASC组高于A、B组(P<0.05),A与B组差异无统计意义。三组均未见明显不良反应。结论氟比洛酚酯超前镇痛应用于腹腔镜胆囊切除术后镇痛,效果确切、使用方便、不良反应小。

Objective To study the preemptive analgesic effect of flurbiprofen axetil injection in the patients undergoing laparoscopic cholecystectomy. Methods Sixty patients undergoing laparoscopic cholecystectomy were randomized to three groups with 20 cases each. The patients in group A were injected intravenously flurbiprofen axetil 50mg, and those in group B flurbiprofen xafon 8 mg before intubation. The patients in group C was given intravenous flurbiprofen axetil injection 50 mg at the end of surgery. The analgesic effect was evaluated by VAS score at 0,1,4,8 and 12 h after surgery, and the postoperative 24 h total analgesic effect, the amount of analgesic drug used postoperatively and the side effects were recorded. Results VAS scores of group C were significantly higher than those of group A and B at all time points （P〈0. 05）, except for 12 h after the surgery. VAS scores of group B were higher than those of group A at the time point of 0 h （P〈0.05）. The value of total 24 h analgesic effect after surgery was significantly lower in group A and B than that in group C（P〈0. 05）. The side effects of three groups were similar. Conclusion Preemptive analgesia with flurbipro- fen axetil for postoperative analgesia is effective, convenient and safe with less side effect in the patients undergoing laparoscopic cholecystectomy.