金纳米团簇功能化及其在生物医学中的应用

Functional Gold Clusters and Their Applications in Biomedicine

对单分子层保护的金纳米团簇(Au-MPCs)进行化学修饰,可制成多元单层修饰的金纳米团簇(Au-MMPCs)。常用的修饰方法为配体交换法,这种方法用带有生物活性基团的巯基化合物或二硫化合物取代Au-MPCs表面的配体分子,形成多元单层修饰的金纳米团簇。巯基化合物或二硫化合物中的生物活性基团可使所制备Au-MMPCs与蛋白质、核酸或细胞膜等作用,使Au-MMPCs具有相应的生物活性,从而能广泛应用于细胞转染、药物传输、酶活性调控等生物医学领域。本文介绍了用Brust-Schiffrin法制备Au-MPCs的机理及影响因素,基于Au-MPCs制备Au-MMPCs的方法及相关机理,综述了Au-MMPCs在生物医学中的应用。

Mixed monolayer protected gold clusters （Au-MMPCs） can be prepared by modifying the monolayer protected gold clusters（Au-MPCs） with various bioactive thiol or disulfide ligands. The interaction of these Au-MMPCs with biomaterials, such as proteins, nucleic acids, and cell membranes, make them useful in cell transfection, drug delivery and enzyme activity regulation. In this paper, the factors that affect the synthesis of gold clusters in Brust-Schiffrin reaction are introduced. The strategies and mechanisms of preparation of mixed monolayer protected gold clusters （Au-MMPCs） based on the Bmst-Schifffin reaction are summarized, in which the ligand exchange reaction are described in detail. The applications of Au-MMPCs in biomedicine are reviewed.