不稳定型心绞痛血清MCP-1变化及普伐他汀的干预效应

Effects of pravastatin on serum monocyte chemoattractant protein-1,tumor necrosis factor-α and interleukin-6 in patients with unstable angina

目的探讨普伐他汀对不稳定型心绞痛(Unstable angina,UA)患者血清单核细胞趋化蛋白-1(MCP-1)、肿瘤坏死因子-α(TNFα)及白细胞介素-6(IL-6)的影响。方法采用放射免疫法及酶联免疫吸附法(ELISA)分别检测了25例UA患者服用普伐他汀前后血清MCP-1、TNFα及IL-6水平。结果UA患者血清MCP-1、TNFα及IL-6水平明显高于对照者,服用普伐他汀4周后血清MCP-1、TNFα及IL-6水平下降。结论MCP-1、TNFα及IL-6可能参与了UA的发病及进展过程,普伐他汀可降低UA患者血清MCP-1、TNFα及IL-6水平,减轻UA患者的炎症反应。

Objective To investigate the effects of pravastatin on serum monocyte chemoattractant protein-1 （ MCP-1）,tumor necrosis factor-α （TNFα） and interleukin-6 （IL-6） in patients with unstable angina （UA）. Methods Serum MCP-1, TNFoand IL-6 were detected by radioimmunoassay and enzyme linked immunosorbent assay （ELISA）4 weeks before and after oral administration of pravastatin in 25 patients with UA. Results The contents of serum MCP- 1, TNFαand IL-6 in patients with UA were significantly increased compared with control group （P= 0. 01）. A significant decreased serum MCP-1, TNFα and IL-6 contents were observed 4 weeks after pravastatin-taken （P = 0.01）. Conclusion These findings indicate that MCP-1, TNFo and IL-6 may play an important role in the pathophysiologic changes of UA and pravastatin has a beneficial effect on decreasing serum MCP-1, TNFα, IL-6 and alleviating inflammatory reaction in patients with UA.