期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

环境毒素对未成熟肾脏的影响 被引量：2

Bad Effect of Environmental Toxins on Developing Kidney
下载PDF
导出
摘要 肾脏是人体主要的排泄器官,它的发育经过原肾、中肾、后肾3个阶段。外界环境中的化学物质、生物及物理因素的毒性作用可损害未成熟肾脏的发育,并严重影响胚胎和儿童的正常发育和身体健康。本文就影响肾脏血流动力学的药物、有机阴离子和有机阳离子、真菌毒素、环境污染物等具体毒素对未成熟肾脏的影响及其临床表现的研究进展作一综述。 The development of the kidney, the major excretory organ after birth, consists of 3 stages： the pronephros, mesonephros and metanephros. The toxical effects of environmental chemicals, biomedical agents and physical agents can greatly influence the developing kidney. They have a gravely bad effect on the development and health of children. This paper seeks to review the toxical effects of drugs that influence the hemodynamics of kidney, organic anions and cations, mycotoxins, elemental contaminants on the developing kidney and the manifestations of toxic nephropathy.
作者 范晔 曾春雨
机构地区 第二军医大学长征医院 第三军医大学大坪医院心内科
出处 《现代生物医学进展》 CAS 2007年第4期622-625,共4页 Progress in Modern Biomedicine
关键词 肾脏 发育 环境 毒素 损害 Kidney Development Environment Toxin Impairment
分类号 R322.6 [医药卫生—人体解剖和组织胚胎学]
  • 相关文献

参考文献35

  • 1HURLEY RM,NAYYAR RP,GOTO M,et al.Renal lesions in young rats induced by Salmonella enteritidis endotoxin[J].Pediatr Nephrol,1989,3:156-161
  • 2MICHAEL J.SOLHAUG,PHILIP M.BOLGEK,PEDRO A.JOSE.The Developing Kidney and Environmental Toxins[J].Pediatrics,2004,1 13:1084-1091
  • 3CUZZOLIN L.DAL CERE M,FANOS V,et al.NSAID-induoed nephrotoxicity from the fetus to the child[J].Drug Saf.,2001,24:9-18
  • 4NIIMURA F,KON V,ICHIKAWA I,et al.The renin-angiotensin system in the development of the congenital anomalies of the kidney and urinary tract[J].Curr Opin Pedlar,2006,18:161-1666
  • 5TOPRAK O.Angiotensin converting enzyme inhibitors and contrast-induced nephropathy[J].Ren Fail,2006,28:99-100
  • 6PAUL M,POYAN MEHR A,KREUTZ R,et al.Phyfiology of local renin-angiotensin systems[J].Physiol Rev,2006,86:747-803
  • 7AVANOGLU A,ERGUN O,BAKIRTAS F,et al.Characteristics of mulfisystem organ failure in neonates[J].J Pediatr Surg,1997,263-266
  • 8NIIMURA F,LABOSKY PA,KAKUCHI J,et al.Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation[J].J Clin Invest.,1995,96:2947-2954
  • 9LACOSTE M,CAI Y,GUICHARNAYD L,et al.Renal tubular dysgenesis,a not uncommon autosomal recessive disorder leading to oligohydramnios:Role of the Renin-Angiotensin system[J].J Am Soc Nephrol,2006,17:2253-2263
  • 10MATSUSAKA T,MIYAZAKI Y,ICHIKAWA I,et al.The renin angiotemin system and kidney development[J].Annu Rev Physiol,2002,64:551-561

二级参考文献8

  • 1Panarotto D,Remillard P,Bouffard L,et al.Insulin resistance affects the regulation of lipoprotein lipase in the postprandial period and in an adipose tissue-specific manner[J].Eur J Clin Invest,2002,32(2):84-92
  • 2Marchesini G,Brizi M,Morselli-Labate AM,et al.Association of nonalcoholic fatty liver disease with insulin resistance[J].AM J Med,1999,107(5):450-455
  • 3Finegood DT,McArthur MD,Kojwang,D,et al,Beta cell mass dynamics in Zucker diabetic fatty rats,Rosiglitazone prevents the rise in net cell death[J].Diabetes,2001,50:1021-1029
  • 4Schmitz Peiffer C.Signaling aspects of insulin resistance in skeletal muscle:metabolisms induced by lipid oversupply[J].Celluar Signaling,2000,12(9-10):583-594
  • 5Cho H,Mu j,Kim Jk,et al.Insulin resistant and a diabetes mellitus-like syndrome in mice lacking the protein linase Akt2(PKB beta)[J].Science,2001,292(5522):1728-1731
  • 6Kausch C,Krutzfeldt J,Witke A,et al.Effects of troglitazone on celluar differentiation,insulin signaling and glucose metabolism in cultured human skeletal muscle cells[J].Biochem Biophys Res Commun,2001,280(3):664-674
  • 7Stumvoll M,Tschritter O,Fritsche A,et al.Association of the T-G polymorphism in adiponectin with obesity,and insulin sensitivity interaction with family history of type 2 diabetes[J].Diabetes,2002,51:37-41
  • 8Keijiu Hiromura,Toshiaki Monkawa,et al.Insulin is a potent survival factor in mesangial cells:Role of thePI3-kinase/Akt pathway[J].Kidney International,2002,61(4):1312-1321

共引文献1

同被引文献13

  • 1OTT K H, ARanibar N, SINGH B, et al. Metabonomics classifies pathways affected by bioactive compounds. Artificial neural net work classification of NMR spectra of plant extracts [ J ]. Phytochemistry, 2003, 62(2): 971-985.
  • 2BOLLARD M E, HOLMES E, LINDON J C, et al. Investigations into biochemical changes due to diurnal variation and estrus cycle in female rats using high-resolution( 1 )H NMR spectroscopy of urine and pattern recognition[ J ]. Anal Biochem, 2001, 295( 2 ): 194-202.
  • 3FIEHN O. Metabolomics——the link between genotypes and phenotypes [ J ]. Plant Mol Biol, 2002, 48( 1-2 ): 155-171.
  • 4GRIFFIN JL, WILLIAMS H J, SANG E, et al. Metabolic profiling of genetic disorders : a muhitissue ( 1 ) H nuclear magnetic resonance spectroscopic and pattern recognition study into dystrophic tissue [ J ]. Anal Biochem, 2001, 293( 1 ): 16-21.
  • 5TAYLOR J, KING R D, ALTMANN T, et al. Application of metabolomics to plant genotype discrimination using statistics and machine learning[ J ]. Bioinformatics, 2002, 18( S2 ): S241-248.
  • 6BRINDLE JT, ANTTI H, HOLMES E, et al. Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics [ J ]. Nat Med, 2002, 8 ( 12 ): 1439-1444.
  • 7BECKWITH-HALL B M, BRINDLE JT, BARTON R H, et al. Application of orthogonal signal correction to minimise the effects of physical and biological variation in high resolution 1H NMR spectra of biofluids[ J ]. Analyst, 2002, 127( 10 ): 1283-1288.
  • 8ABBES S, OUANES Z, BEN SALAH-ABBES J, et al. The protective effect of hydrated sodium calcium aluminosilicate against haematological, biochemical and pathological changes induced by Zearalenone in mice[ J ] .Toxicon. 2006.47( 5 ):567-574.
  • 9中华人民共和国卫生部,中国国家标准化管理委员会.GB2761-2005食品中真菌毒素限量[s].北京:中国标准出版社,2005.
  • 10European Communities. Commission regulation ( EC ) No 466/2001 of 8 March 2001 setting maximum levels for certain contaminants in foodstuffs [ EB/OL ]. [ 2009-01-01 ]. http: //www.cfsan.fda.gov/ -acrobat/iuecrega.pdf.

引证文献2

二级引证文献3

现代生物医学进展
2007年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部