盆炎清颗粒对混合菌液所致大鼠慢性盆腔炎的作用

Therapeutic effects of Penyanqing Granules(盆炎清颗粒) on chronic pelvic inflammation induced by a mixture of bacterium suspension in rats

目的:研究盆炎清颗粒对混合菌液所致大鼠慢性盆腔炎的治疗作用。方法:将大鼠单侧子宫内膜器械划伤,注入大肠杆菌与金黄色的葡萄球菌的混合菌液,制备大鼠慢性盆腔炎动物模型。造模10天后。ig给药20天,观察盆炎清颗粒对模型大鼠相关各项指标的影响。结果:盆炎清颗粒可以抑制感染子宫肿胀率,降低血清MDA、IL-6水平,对慢性盆腔炎病理改变也有明显减轻。结论:盆炎清颗粒对混合菌液所致大鼠慢性盆腔炎具有明显的治疗作用。

Objective： To investigate the therapeutic effects of Penyanqing Granules on chronic pelvic inflammation induced by a mixture of bacterium suspension in rats. Method ： Chronic pelvic inflammation of rats was caused by injecting a mixture of bacterium suspension into injured uterus. After 10 days of model induction, animals were randomly divided into five groups： sham -operation , model, and 1.25 g/kg,2.5 g/kg and 5g/kg dose of Penyanqing Granules. The influence of Penyanqing Granules on the model rats after 20 days of therapeutic ig Penyanqing Granules were observed. Result： Penyanqing Granules at three dosages of 1.25 g/kg ,2：5 g/kg and 5g/kg could significantly reduce the serum MDA and IL - 6 level. Penyanqing Granules could significantly inhibit the inflammatory rection and morphologic alteration of model uterus. Conclusion ： Penyanqing Granules has the therapeutic effect on chronic pelvic inflammation induced by a mixture of bacterium suspension in rats.