动脉硬度指数与冠状动脉病变严重程度关系的探讨

Study on the relationship between arterial stiffness index and the severity degree of coronary atherosclerosis

目的:探讨动脉硬度指数(Arterial stiffness index ASI)与冠状动脉粥样硬化程度的相关性。方法:396例行冠状动脉造影的患者,采用CardioVision MS-2000动脉硬度测量仪测定ASI作为反映动脉弹性的指标。根据ASI水平分为三组:Ⅰ组(ASI0-70,186例),Ⅱ组(ASI71￣140,108例),Ⅲ组(ASI>140,102例)。冠状动脉病变严重程度用冠脉病变支数来评价。结果:三组间年龄、高血压史、糖尿病史、收缩压及冠状动脉病变严重程度有显著的差别,平均病变血管支数Ⅲ组>Ⅱ组>Ⅰ组(P<0.05)。单因素相关分析显示,年龄、收缩压、高血压史、糖尿病史、脂蛋白(a)、尿酸、ASI与病变血管支数呈正相关,高密度脂蛋白胆固醇与病变血管支数呈负相关(P<0.05)。多因素Logistic回归分析结果表明ASI、高密度脂蛋白胆固醇、脂蛋白a是冠心病的独立相关因素。结论:ASI是一种评价动脉弹性功能的良好指标,可以提供冠状动脉病变严重程度的信息。

Objective：To investigate the relationship between arterial stiffness index （ASI） and the severity degree of coronary atherosclerosis. Methods iA total of 396 patients underwent coronary angiograph and the measurement of ASI using CardioVision MS- 2000 arterial stiffness detector and then they were clivided into three groups：group Ⅰ （ASI 0-70,186 patients）, group Ⅱ （ASI 71- 140,108 patients） and group Ⅲ （ASI〉140,102 patients）. The severity degree of coronary heart disease was evaluated by the numbers of involved coronary arteries. Results：There were significant differences in age, history of high blood pressure, diabetes history, systolic blood pressure, and the severity degree of coronary heart disease among three groups. The mean number of involved coronary arteries was highest in group Ⅲ , foUowely by group Ⅱ and group Ⅰ （P 〈 0.05 ）. There was a positive correlation between age, systolic blood pressure, high pressure history, diabetes history, lipoprotein （a）, uric acid, ASI and the number＇of involved coronary arteries showed by single factor .correlation analysis methods. However, there was a negative correlation between high-density lipoprotein cholesterols （HDL-C） and the number of involved coronary arteries （P 〈 0.05 ）. ASI, HDL-C and lipoprotein （a） were independent risk factors of coronary heart disease showed by multiple factor logistic regression analysis method. Conclusion： ASI may be a good index reflecting arterial elasticity and can provide valuable information of the severity degree of involved coronary arteries.