中晚期宫颈癌超选择动脉灌注化疗栓塞术42例临床分析

The Clinical Value of Interventional Therapy in Advanced Cervical Carcinoma

目的:探讨超选择动脉灌注化疗栓塞术(以下简称介入治疗)对中晚期宫颈癌的临床治疗价值。方法:选择经活检确诊为宫颈癌,临床分期Ⅱb以上患者42例,进行介入治疗1～3次后观察其临床症状及肿瘤大小、病理变化。结果:经介入治疗后25例临床症状完全缓解,10例明显缓解,5例中度缓解,总缓解率95.2%(40/42);CR10例,PR27例,SD5例,近期有效率为88.1%(37/42);33例获降期后手术切除,占78.6%(33/42),28例术后至今无复发或转移;肿瘤组织病理检查显示,介入治疗后癌细胞变性坏死,以治疗后48小时明显,并随时间推移而增加。结论:介入治疗对中晚期宫颈癌有良好的近期疗效,是一种增加降期后手术切除率、提高疗效和生存质量的有效方法。

Objective： To evaluate the clinical value of interventional therapy in advanced cervical carcinoma. Methods：42 cases of cervical carcinoma （stage Ⅱ b more than） were treated with intervention 1 - 3 times.The clinical symptoms, tumor size, and pathological changes were observed. Results： After intervention, symptoms for 25 cases were relieved completely,10 cases were relieved obviously, and 5 cases were relieved partially.The total relieve rate was 95.2% （40/42）.Of those tumor masses, CR 10 cases, PR 27 cases, SD 5 cases, the recently effective rate was 88.1% （37/42）. 33 cases underwent secondary operation specialized agencies, accounting for 78.6% （33/42） .None of 28 patients occurred postoperative recurrence or metastasis in follow-up of 〈 12 -40 months; Histologic examination revealed that the tumor cell necrosis significantly after 48 hours of interventional therapy,and have increased with time-lapse. Conclusions： Interventional treatment in advanced cervical carcinoma has a good shod-time results, it can increase the opportunity of Ⅱ phase operation.It isan efficient method of increasing the survival rate and lessen side effect.