细胞因子信号转导抑制因子2在乳腺癌中的表达

Expression of suppressor of cytokine signaling 2 in breast carcinoma by tissue microarray

目的:检测细胞因子信号转导抑制因子2(supressors of cytokine signaling 2,SOCS2)蛋白在乳腺组织中的表达,探讨SOCS2的表达与乳腺癌临床病理资料之间的关系。方法:构建乳腺癌、癌旁组织及良性病变组织微阵列(tissue microarray);用免疫组织化学S-P法检测171例乳腺癌、18例癌旁乳腺组织、20例乳腺良性病变SOCS2、ER、PR、cerbB2、p53和Ki-67的表达。结果:乳腺癌中SOCS2阳性率为57．89％(99／171),癌旁乳腺组织为94．44％(17／18),乳腺良性病变为75％(15／20);乳腺癌组织中SOCS2的表达在不同TNM分期、不同组织学分级、淋巴结有无转移和Ki-67阳性及阴性表达下有显著差异(P< 0．05)。结论:SOCS2的表达降低可能与乳腺癌发生和预后不佳相关。

Objective： To investigate the expression of suppressor of cytokine signaling 2 （SOCS2） in breast carcinoma tissues and to discuss its relationship with clinical pathological data of breast carcinoma patients. Methods： The tissue microarray for 171 cases of breast carcinoma specimens, 18 adjacent tissues and 20 breast benign lesions were established. Then the expression of SOCS2, ER, PR, cerbB2, p53 and Ki-67 was detected by tissue microarray technique and S-P immunohistochemistry. Results： Positive rates of the SOCS2 protein in the breast carcinoma specimens, adjacent tissues and breast benign lesion were 57.89%（ 99/171 ）, 94.44 % （ 17/18 ）, and 75% （ 15/20 ）, respectively. The expression of SOCS2 was significantly different in breast carcinoma tissues of different TNM classification, different histological grades, and with or without Ki-67 expression and lymphatic metastasis（P〈0.05）. Conclusion： The lower expression of SOCS2 might contribute to oncogenesis of breast carcinoma and poor prognosis.