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昆明地区汉族人群中ecNOS基因第四内含子VNTR多态性分布 被引量：1

The Distribution of Tandem Repeat Polymorphism of ecNOS Gene in Kunming Han Nationality
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摘要 目的探讨内皮源性一氧化氮合酶(ecNOS)基因第四内含子27 bp数目可变的串联重复序列(VNTR)多态性在中国昆明汉族人群中的分布.方法在223例无亲缘关系的中国昆明汉族人群中,采用聚合酶链反应(PCR)技术检测ecNOS基因第4内含子的27 bp VNTR多态性标记.结果在中国昆明汉族人群中含有4 a(4重复系列)等位基因的频率为0.08,本组与国内广东、北京汉族人群中的检测结果相比无显著性差异,与美国黑人相比有显著性差异.结论中国昆明地区汉族人群ecNOS基因第四内含子27bp VNTR多态性分布与美国黑人不同. Objective To study the distribution of variable number tandem repeat polymorphism of ecNOS （endothelial constitutive Nitric Oxide Synthase） gene in Kunming Han nationality. Methods The genotypes of ecNOS were detected by PCR in 223 unrelated people of Han nationality. Results Allele frequency of the 4a was 0. 08 in Kunming Han nationality. The overall distribution of allele frequencies was similar to those in Beijing and Guangdong but significantly different from that of African Americans. Conclusions The overall distribution of allele frequencies in China differed significantly from that in African Americans.
作者 徐玉善 张敏 宋滇平 李红 刘华 张旭祥
机构地区 昆明医学院第一附属医院内分泌与代谢病科 昆明医学院第一附属医院糖尿病科 昆明医学院第一附属医院检验科
出处 《昆明医学院学报》 2007年第2期27-30,共4页 Journal of Kunming Medical College
关键词 一氧化氮合酶基因 内含子 多态性 分布 Nitric oxide synthase genes Intro Polymorphism Distribution
分类号 R587.2 [医药卫生—内分泌]
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参考文献8

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二级参考文献13

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昆明医学院学报
2007年 第2期

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