川崎病患儿急性期冠脉扩张与血小板参数变化关系的研究

The Relation between Coronary Artery Dilation and Platelet Parameter Changes in Children with Kawasaki Disease

目的探讨川崎病(KD)冠状动脉异常患儿与血小板参数变化之间的关系.方法采用Xe-2100型全自动血细胞分析仪测定54例KD急性期患儿的外周血血小板数(PLT)、平均血小板体积(MPV)、血小板体积分布宽度(PDW),并与30例健康儿童进行比较.冠状动脉扩张经心脏彩色超声心动图检查确定.结果KD患儿急性期PLT升高,PDW下降均较对照组有统计学差异(P<0.05).急性期冠脉扩张的患儿MPV较无冠脉扩张的患儿高,且差异有显著性(P<0.01).结论KD急性期血小板参数的变化与冠脉扩张有相关性,检测血小板参数的变化对KD的诊断、治疗及预后判断有一定的参考价值.

Objective To investigate the relation between coronary artery dilation （CAD） and platelet parameter changes in children with Kawasaki disease （KD）. Methods The platelet total （PLT）, mean platelet volume （MPV）, platelet distribution width （PDW） and their changes were measured by Xe -2100 full -automatic hemocytometer in 54 children with acute KD. The results were compared with those in 30 cases of normal children. The level of CAD was determined by the cardiology ultrasonic examination. Results The levels of increasing PLT and decreasing PDW in children with acute KD were higher than that in control group （P 〈 0. 05 ）. The level of MPV in children with CAD was higher than those with no CAD involvement. There was significant difference between two groups （P 〈 0. 01 ）. Conclusion The platelet changes positively correlated with CAD in children with acute KD, so examining the changes of platelet parameter is helpful to diagnose, estimate prognosis and guide the treatment of KD.