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分娩发动前后胎盘中白细胞抗原G1 mRNA和NK细胞的变化 被引量：2

Changes of HLA-G1 mRNA expression and NK cell in placenta during labor onset
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摘要 目的:检测胎盘及蜕膜组织中白细胞抗原G1(HLA-G1)mRNA和NK细胞在足月妊娠分娩发动前后的变化,探讨其在分娩发动中的作用。方法:通过RT-PCR法检测足月妊娠晚期未临产组(剖宫产组)和临产组胎盘组织中HLA-G1 mRNA的表达,并用免疫组织化学方法测定蜕膜中NK细胞的数量。结果:与未临产组相比临产组胎盘组织中HLA-G1 mRNA表达明显下降,差异有统计学意义(P<0.05);临产组蜕膜中NK细胞数量明显多于未临产组(P<0.05)。结论:分娩发动时胎盘组织表达HLA-G1mRNA下降,蜕膜组织中NK细胞数量明显增多,推测HLA-G1表达下降激活NK细胞可能参与了分娩发动。 Objective： To investigate the changes of HLA-G1 mRNA expression and NK cell number in placenta during labor onset. Method：RT-PCR was used to determine HLA- G1 mRNA expression in placenta of both in no-labor （cesarean section group） and labor group. Immunochemistry was used to identify the NK cell in deciduas in both groups. Result： HLA-GlmRNA remarkably decreased while NK cell notably increased in in labor group compared with cesarean section group （ P 〈 0.05 ）. Conclusion： Activating NK cell by decreased HLA-G1 may trigger labor onset.
作者 何明 邹丽 朱剑文
机构地区 华中科技大学同济医学院附属协和医院妇产科
出处 《现代妇产科进展》 CSCD 北大核心 2007年第3期197-198,共2页 Progress in Obstetrics and Gynecology
关键词 HLA抗原 杀伤细胞 天然 分娩发作 妊娠 HLA antigens Killer cell,nature Labor onset Pregnancy
分类号 R714.3 [医药卫生—妇产科学]
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现代妇产科进展
2007年 第3期

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