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T细胞淋巴瘤与外周血嗜酸粒细胞增多相关性及其发生机制研究进展 被引量：1

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摘要 T细胞淋巴瘤与外周血嗜酸粒细胞增多之间的关系已经确立，是由肿瘤性T细胞或具有异常免疫表型的T细胞群分泌大量Th2型细胞因子，包括粒-单核细胞集落刺激因子（GM—CSF）、IL-4、IL-5等导致外周血嗜酸粒细胞增多。具有异常表型的T细胞克隆已被证实具有恶性转化潜能，很容易发展成T细胞淋巴瘤。有些诊断为特发性高嗜酸粒细胞综合征（IHES）或高嗜酸粒细胞综合征（HES）的病例现已证明是由于免疫表型异常、克隆性或非克隆性的T细胞造成的嗜酸粒细胞增多，故此类病例不再分类为HES。不管何种原因引起嗜酸粒细胞增多，都将导致器官、组织受损。
作者 王微 陈辉树
机构地区 中国医学科学院、中国协和医科大学血液学研究所、血液病医院
出处 《中华血液学杂志》 CAS CSCD 北大核心 2007年第4期285-288,共4页 Chinese Journal of Hematology
关键词 嗜酸粒细胞增多 T细胞淋巴瘤 外周血 高嗜酸粒细胞综合征 TH2型细胞因子 细胞集落刺激因子 生机 多相
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献30

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共引文献19

同被引文献6

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中华血液学杂志
2007年 第4期

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