细胞外ATP对大鼠脊髓损伤后运动功能恢复的影响

Effects of extracellular ATP on the recovery of motor function after spinal cord injury in rats

目的研究细胞外ATP对大鼠脊髓损伤后运动功能恢复的影响。方法健康成年Wistar大鼠20只,雌雄不限,体重280-320 g,平均300 g,制作成脊髓打击伤动物模型,并随机分为两组:A组(ATP组)和B组(对照组),每组10只。伤后1、3、7、14、28 d用改良的Tarlov评分、斜板试验观察大鼠运动功能的恢复情况。结果大鼠脊髓损伤后A组改良的Tarlov评分、斜板试验优于对照组,在14 d和28 d,改良的Tarlov评分、斜板试验A组明显优于B组(P<0.05)。结论细胞外ATP能促进大鼠脊髓损伤后运动功能的恢复。

Objective To investigate the effects of extracellular ATP on the recovery of motor function after spinal cord injury in rats. Methods Twenty healthy adult rats were randomly divided into two groups after contusion injury was performcd by the weight drop method at T10 with Allen impactor. Group A （ATP group） and group B （control group） each had ten rats. At days 1, 3, 7, 14 and 28 after injury, the recovery of motor function after spinal cord injury in rats was assessed with modified Tarlov scores and slanting board test. Results Modified Tarlov scores and slanting board test were bcttcr in group A than in group B after spinal cord injury in rats. Significant difference was found in modified Tarlov scorcs and slanting board test between thc two groups at days 14 and 28 after injury （P〈0.05）. Conclusion Extracellular ATP can promote the recovery of motor function after spinal cord injury in rats.