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C-myc蛋白在脑胶质瘤组织中的表达及意义 被引量：2

The expression and significance of C-myc in gliomas
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摘要 目的探讨C-myc蛋白在脑胶质瘤组织中的表达情况及其与肿瘤恶性程度之间的关系。方法应用免疫组织化学方法检测40例脑胶质瘤组织标本中的C-myc蛋白表达情况。结果C-myc蛋白阳性染色主要定位于脑胶质瘤细胞的胞浆或胞核中,其表达强度与脑胶质瘤的组织学分级相关,随着脑胶质瘤恶性程度的增高,C-myc的表达强度和阳性细胞百分比也随之逐渐增加,各级之间均有显著性差异(P<0.05)。结论C-myc蛋白在脑胶质瘤组织中呈过度表达,并与脑胶质瘤的恶性程度密切相关。 Objective To explore the expression of C-myc in gliomas and its clinical significance. Methods The expression of C-myc in 40 cases of gliomas was examined with immunohistochemical technique. The relationship of the expression of C-myc with the histological grades of the gliomas was analyzed. Results C-myc overexpression in the gliomas and the level of the expression were related to the histological grades of the gliomas. With higher malignancy, the expression level increased. The expression of C-myc in the gliomas of different grades was significantly different. Conclusion C-myc overexpression in the gliomas is related to the tumor malignancy.
作者 周任 刘勇 王睿智 吕健 王康敏 赵世平 师蔚
机构地区 西安交通大学医学院第二附属医院神经外科 西安交通大学医学院人体解剖学与组织胚胎学系 西安交通大学医学院第二附属医院病理科
出处 《西安交通大学学报（医学版）》 CAS CSCD 北大核心 2007年第2期203-204,219,共3页 Journal of Xi’an Jiaotong University（Medical Sciences）
关键词 胶质瘤 C-MYC蛋白 免疫组织化学 glioma C-myc immunohistochemistry
分类号 R730.55 [医药卫生—肿瘤]
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参考文献6

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共引文献2

同被引文献22

  • 1付荣霞,杨艳梅,张春艳.金雀异黄素对人胃腺癌细胞中Akt及其磷酸化蛋白表达的影响[J].世界华人消化杂志,2007,15(10):1055-1059. 被引量：7
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西安交通大学学报（医学版）
2007年 第2期

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