干扰素中和抗体对重组α干扰素治疗尖锐湿疣疗效的影响

Effectivenes of Neutralizing Anti-interferon Antibodies in Patients with Condyloma Acominatam Treated with Recombinant Interferon Alpha

目的观察干扰素中和抗体（NA）对重组α干扰素（IFN-α）治疗尖锐湿疣疗效的影响及临床意义。方法86例尖锐湿疣患者治疗前采用抗病毒生物中和法测定NA阴性者，经微波或CO2激光治疗后给予局部干扰素治疗，每次3×10^6 IU，每周2次，疗程3～9个月（平均6个月），疗程中定期测定NA。结果86例患者治疗后NA阳性11例（12．79％），其中治疗后3，4，5，6及6个月后检出分别是1，2，3，2例及3例。NA阳性组HPV复发率（72．72％）高于NA阴性组（25．33％）；临床治愈率（27．27％）低于NA阴性（74．67％），两组差异有显著性（P〈0．01）。结论IFN-α治疗尖锐湿疣NA阳性率不高，但NA可以影响IFN-α的疗效。

Objective To investigate the clinical effects of interferon-αlpha （IFN-α） neutralizing antibodies （NA） in patients with Condyloma Acominatum treated with recombinant interferon alpha. Methods NA was assayed by antiviral neutralizing bioassay in 86 Condyloma Acominatum patients treated with recombinant interferon alpha. For each patient with micro wave or CO2 laser were treated with 3 × 10^6 IU recombinant intederon-alpha subcutaneously, two times weekly, for 3 - 9 （ median 6 ） months. NA with an antiviral neutralizing bioassay assay were pedormed during therapy. Results NA were detected in 11 of 86 （ 12.79% ） , patients after receiving the therapy, with 1 patients in 3 months, 2 patients in 4 months, 3 patients in 5 months, 2 patients in 6 months and 3 patients in more than 6 months. The vires recrudescence rate were higher in NA positive group（72.72% ） than that in NA negative group （25, 33% ）, and curing rate were less in NA positive group （27.27%） than that in NA negative group （74.67%） （ P 〈 0.01 ）. Conclusion NA incidence was low in patients with Condyloma Acominatum patients treated with recombinant in terferon alpha. NA reduced the effectiveness of IFN.