血管内皮生长因子受体激酶插入嵌合受体在前列腺癌及良性前列腺增生组织中的表达

Expression of Kinase Insert Domain-containing Receptor in Prostate Adenocarcinoma

目的:探讨血管内皮生长因子受体KDR在PCa组织中的表达及其与PCa病理学分级之间的关系。方法:用KDR多克隆抗体对48例PCa组织和20例BPH组织石蜡包埋切片进行免疫组化染色。分析KDR在PCa、BPH组织中的表达情况以及表达强度与PCa组织病理学分级之间的关系。结果:KDR在73%PCa组织、30%BPH组织中呈不同程度的阳性表达。在PCa组织中呈明显高表达(P<0.05),表达强度与前列腺癌的Gleason评分无相关性(r=0.09,P>0.05)。结论:KDR在PCa组织中的表达明显增高,有望成为治疗PCa的一个新靶点。

Objective： To investigate the correlation between the expression of the kinase insert domain-containing receptor （KDR） and the histological grade of prostate adenocarcinoma. Methods ： Forty-eight samples of prostate adenocarcinoma tissues and 20 sampies of benign prostatic hypertrophy （BPH）tissues were studied by LsAB immunohistocbemical staining. Results： The positive expression rate of KDR was 73% in prostate adenocarcinoma and 30% in BPH. The expression of KDR was stronger in prostate adenocarcinoma, and there was no relationship between staining intensity and the histological grade of carcinoma. Conclusion ： KDR, expressed more highly in prostate adenocarcinoma, promises to be a new target in the treatment of prostate adenocarcinoma.