摘要
目的:探讨血管内皮生长因子受体KDR在PCa组织中的表达及其与PCa病理学分级之间的关系。方法:用KDR多克隆抗体对48例PCa组织和20例BPH组织石蜡包埋切片进行免疫组化染色。分析KDR在PCa、BPH组织中的表达情况以及表达强度与PCa组织病理学分级之间的关系。结果:KDR在73%PCa组织、30%BPH组织中呈不同程度的阳性表达。在PCa组织中呈明显高表达(P<0.05),表达强度与前列腺癌的Gleason评分无相关性(r=0.09,P>0.05)。结论:KDR在PCa组织中的表达明显增高,有望成为治疗PCa的一个新靶点。
Objective: To investigate the correlation between the expression of the kinase insert domain-containing receptor (KDR) and the histological grade of prostate adenocarcinoma. Methods : Forty-eight samples of prostate adenocarcinoma tissues and 20 sampies of benign prostatic hypertrophy (BPH)tissues were studied by LsAB immunohistocbemical staining. Results: The positive expression rate of KDR was 73% in prostate adenocarcinoma and 30% in BPH. The expression of KDR was stronger in prostate adenocarcinoma, and there was no relationship between staining intensity and the histological grade of carcinoma. Conclusion : KDR, expressed more highly in prostate adenocarcinoma, promises to be a new target in the treatment of prostate adenocarcinoma.
出处
《中华男科学杂志》
CAS
CSCD
2007年第4期324-326,共3页
National Journal of Andrology