期刊文献+

血管内皮生长因子受体激酶插入嵌合受体在前列腺癌及良性前列腺增生组织中的表达 被引量:3

Expression of Kinase Insert Domain-containing Receptor in Prostate Adenocarcinoma
下载PDF
导出
摘要 目的:探讨血管内皮生长因子受体KDR在PCa组织中的表达及其与PCa病理学分级之间的关系。方法:用KDR多克隆抗体对48例PCa组织和20例BPH组织石蜡包埋切片进行免疫组化染色。分析KDR在PCa、BPH组织中的表达情况以及表达强度与PCa组织病理学分级之间的关系。结果:KDR在73%PCa组织、30%BPH组织中呈不同程度的阳性表达。在PCa组织中呈明显高表达(P<0.05),表达强度与前列腺癌的Gleason评分无相关性(r=0.09,P>0.05)。结论:KDR在PCa组织中的表达明显增高,有望成为治疗PCa的一个新靶点。 Objective: To investigate the correlation between the expression of the kinase insert domain-containing receptor (KDR) and the histological grade of prostate adenocarcinoma. Methods : Forty-eight samples of prostate adenocarcinoma tissues and 20 sampies of benign prostatic hypertrophy (BPH)tissues were studied by LsAB immunohistocbemical staining. Results: The positive expression rate of KDR was 73% in prostate adenocarcinoma and 30% in BPH. The expression of KDR was stronger in prostate adenocarcinoma, and there was no relationship between staining intensity and the histological grade of carcinoma. Conclusion : KDR, expressed more highly in prostate adenocarcinoma, promises to be a new target in the treatment of prostate adenocarcinoma.
出处 《中华男科学杂志》 CAS CSCD 2007年第4期324-326,共3页 National Journal of Andrology
关键词 前列腺腺癌 良性前列腺增生 血管内皮生长因子 激酶插入嵌合受体 prostate adenocarcinoma benign prostate hypertrophy vascular endothelial growth factor KDR
  • 相关文献

参考文献10

  • 1Meada K,Chung YS,Ogawa Y,et al.Prognostic value of vascular endothelial growth factor expression in gastric carcinoma[J].Cancer,1996,77(5):858-863.
  • 2Boocock CA,Charnock-Jones DS,Sharkey AM,et al.Expression of vacular endothelial growth factor and its receptors flt and KDR in ovarian carcinoma[J].J Ntal Cancer Inst,1995,87(7):506-516.
  • 3金铁雄,李晓刚,吴文元,朴东明,冯景琰,桑晶.环氧化酶2和血管内皮细胞生长因子在前列腺癌组织中的表达及意义[J].中华男科学杂志,2006,12(3):207-210. 被引量:8
  • 4王亮,陈昭颉,王庆堂,曹文峰,简燚,汪盛贤,张秉鸿.低氧诱导因子1α及血管内皮生长因子在前列腺癌中的表达及意义[J].中华男科学杂志,2006,12(1):57-59. 被引量:8
  • 5Smolej L,Beneova P.Significance of angiogenesis in malignant tumors[J].Acta Medica (Hradec Kralove) Suppl,2005,48(2):69-72.
  • 6Speirs V,Atkin SL.Production of VEGF and expression of the VEGF receptors Flt-1 and KDR in primary cultures of epithelial and stromal cells derived from breast tumor[J].Br J Cancer,1999,80(5-6):898-903.
  • 7Takahashi Y,Kitadai Y,Bucana CD,et al.Expression of vascular endothelial growth factor and its receptor,KDR,correlates with vascularity,metastasis,and proliferation of human colon cancer[J].Cancer Res,1995,55(18):3964-3968.
  • 8Strawn LM,McMahon G,Schreck R,et al.Flk-1 as a target for tumor growth inhibition[J].Cancer Res,1996,56(15):3540-3545.
  • 9Song Shumei,Wujian,Shou Chengchao.Expression of VEGF receptor KDR in different originated carcinomas[J].Chin J Cancer Res,1998,10(3):104-108.
  • 10Kollermann J,Helpap B.Expression of vascular endothelial growth factor(VEGF) and VEGF receptor Flk-1 in benign,premalignant,and malignant prostate tissue[J].Am J Clin Pathol,2001,116(1):115-121.

二级参考文献12

共引文献14

同被引文献33

  • 1田昕,王萍萍,刘云鹏,侯科佐,金波,罗颖,曲秀娟.蟾蜍灵在诱导HL-60细胞凋亡过程中对Bcl-2和PKC的影响[J].中国实验血液学杂志,2007,15(1):67-71. 被引量:22
  • 2王娟.血管内皮生长因子及其受体在抗肿瘤治疗应用的研究进展[J].中国医药工业杂志,2007,38(5):381-386. 被引量:9
  • 3孟志强,沈晔华,杨培英,Robert Newman,贝文英,张颖,葛勇前,Lorenzo Cohen,Razelle Kurzrock,刘鲁明.华蟾素治疗肝癌、肺癌、胰腺癌的Ⅰ期临床研究:初步报道[J].中国癌症杂志,2007,17(5):376-379. 被引量:29
  • 4Salani D, Taraboletti G, Rosano L, et al. Endothelin-1 induces an angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo[ J]. Am J Pathol, 2000, 157 (5) : 1703-1711.
  • 5Brown LF, Berse B, Jackman RW, et al. Expression of vascular permeability factor( vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract[J]. Cancer Res, 1993, 53(19) :4727-4735.
  • 6Yoshiji H, Gomez DE, Shibuya M, et al. Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer[ J]. Cancer Res, 1996, 56 (9): 2013-2016.
  • 7Abdou AG, Aiad H, Asaad N,et al. Immunohistochemical evaluation of vascular endothelial growth factor (VEGF) in colorectal carcinoma [J]. J Egypt Natl Canc Inst, 2006, 18(4) :311-322.
  • 8Clauss M. Molecular biology of the VEGF and the VEGF receptor family[J]. Semin Thromb Hemost, 2000, 26(5) :561-569.
  • 9Kraft A, Weindel K, Ochs A, et al. V ascular endothelial growth factor in the sera and effusions of patients with malignant and nonmalignant disease[J].Cancer. 1999, 85(1) : 178-187.
  • 10Weidner N. Intratumor microvessel density as a prognostic factor in cancer[ J]. Am J Pathol, 1995, 147( 1 ) :9-19.

引证文献3

二级引证文献15

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部